Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2807605..2808440 | Replicon | chromosome |
| Accession | NZ_CP055219 | ||
| Organism | Shigella flexneri strain STEFF_12 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | HUZ41_RS13910 | Protein ID | WP_239636889.1 |
| Coordinates | 2808063..2808440 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | F4TIK7 |
| Locus tag | HUZ41_RS13905 | Protein ID | WP_001285605.1 |
| Coordinates | 2807605..2807973 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ41_RS13865 (2803923) | 2803923..2804168 | - | 246 | Protein_2728 | IS91 family transposase | - |
| HUZ41_RS13870 (2804230) | 2804230..2805465 | - | 1236 | Protein_2729 | IS3 family transposase | - |
| HUZ41_RS13875 (2805551) | 2805551..2805976 | + | 426 | WP_000422741.1 | transposase | - |
| HUZ41_RS13880 (2805973) | 2805973..2806323 | + | 351 | WP_000624718.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HUZ41_RS13885 (2806354) | 2806354..2806566 | + | 213 | Protein_2732 | IS66 family transposase | - |
| HUZ41_RS13890 (2806552) | 2806552..2806725 | + | 174 | Protein_2733 | antirestriction protein | - |
| HUZ41_RS13895 (2806741) | 2806741..2807217 | + | 477 | WP_004025728.1 | RadC family protein | - |
| HUZ41_RS13900 (2807304) | 2807304..2807525 | + | 222 | Protein_2735 | DUF987 domain-containing protein | - |
| HUZ41_RS13905 (2807605) | 2807605..2807973 | + | 369 | WP_001285605.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HUZ41_RS13910 (2808063) | 2808063..2808440 | + | 378 | WP_239636889.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| HUZ41_RS13915 (2808437) | 2808437..2808586 | + | 150 | Protein_2738 | DUF5983 family protein | - |
| HUZ41_RS13920 (2808662) | 2808662..2808859 | + | 198 | WP_086795284.1 | DUF957 domain-containing protein | - |
| HUZ41_RS13925 (2808944) | 2808944..2809786 | + | 843 | WP_001696593.1 | DUF4942 domain-containing protein | - |
| HUZ41_RS13930 (2810254) | 2810254..2810561 | + | 308 | Protein_2741 | IS3 family transposase | - |
| HUZ41_RS13935 (2810844) | 2810844..2811458 | - | 615 | WP_032322729.1 | type III secretion system LEE effector EspF | - |
| HUZ41_RS13940 (2811543) | 2811543..2811821 | - | 279 | WP_000245815.1 | type III secretion system LEE needle protein cochaperone EscG | - |
| HUZ41_RS13945 (2811827) | 2811827..2812048 | - | 222 | WP_001053840.1 | type III secretion system LEE needle filament protein EscF | - |
| HUZ41_RS13950 (2812083) | 2812083..2812490 | - | 408 | WP_000228584.1 | LcrR family type III secretion system chaperone CesD2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | espF / escG / escF / cesD2 / espB / espD / espA / sepL / escD / eae / cesT / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG | 2799019..2845367 | 46348 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13914.90 Da Isoelectric Point: 8.5163
>T162007 WP_239636889.1 NZ_CP055219:2808063-2808440 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITPGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITPGKHPGAKQ
Download Length: 378 bp
>T162007 NZ_CP071464:2048842-2048944 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 123 a.a. Molecular weight: 13652.48 Da Isoelectric Point: 6.0601
>AT162007 WP_001285605.1 NZ_CP055219:2807605-2807973 [Shigella flexneri]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT162007 NZ_CP071464:c2048951-2048806 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|