Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
| Location | 4964240..4964819 | Replicon | chromosome |
| Accession | NZ_CP055216 | ||
| Organism | Raoultella ornithinolytica strain STEFF_15 | ||
Toxin (Protein)
| Gene name | shpA | Uniprot ID | A0A808YBH6 |
| Locus tag | HUZ43_RS23720 | Protein ID | WP_032716505.1 |
| Coordinates | 4964532..4964819 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | shpB | Uniprot ID | - |
| Locus tag | HUZ43_RS23715 | Protein ID | WP_004857518.1 |
| Coordinates | 4964240..4964545 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ43_RS23690 (HUZ43_23585) | 4959447..4960511 | - | 1065 | WP_004857527.1 | DUF2955 domain-containing protein | - |
| HUZ43_RS23695 (HUZ43_23590) | 4960501..4961568 | - | 1068 | WP_004857525.1 | HlyD family secretion protein | - |
| HUZ43_RS23700 (HUZ43_23595) | 4961575..4962039 | - | 465 | WP_004857523.1 | MarR family transcriptional regulator | - |
| HUZ43_RS23705 (HUZ43_23600) | 4962330..4962494 | - | 165 | WP_004857521.1 | DUF1127 domain-containing protein | - |
| HUZ43_RS23710 (HUZ43_23605) | 4962672..4964084 | + | 1413 | WP_015585221.1 | PLP-dependent aminotransferase family protein | - |
| HUZ43_RS23715 (HUZ43_23610) | 4964240..4964545 | - | 306 | WP_004857518.1 | BrnA antitoxin family protein | Antitoxin |
| HUZ43_RS23720 (HUZ43_23615) | 4964532..4964819 | - | 288 | WP_032716505.1 | BrnT family toxin | Toxin |
| HUZ43_RS23725 (HUZ43_23620) | 4964936..4965355 | - | 420 | WP_015585224.1 | FosA family fosfomycin resistance glutathione transferase | - |
| HUZ43_RS23730 (HUZ43_23625) | 4965349..4966257 | - | 909 | WP_015585225.1 | LysR family transcriptional regulator | - |
| HUZ43_RS23735 (HUZ43_23630) | 4966345..4967127 | + | 783 | WP_015585226.1 | NAD(P)H-dependent oxidoreductase | - |
| HUZ43_RS23740 (HUZ43_23635) | 4967275..4967853 | + | 579 | WP_004857495.1 | TetR/AcrR family transcriptional regulator | - |
| HUZ43_RS23745 (HUZ43_23640) | 4967997..4968809 | + | 813 | WP_004857492.1 | winged helix-turn-helix domain-containing protein | - |
| HUZ43_RS23750 (HUZ43_23645) | 4968806..4969324 | + | 519 | WP_015585229.1 | FidL-like protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11131.57 Da Isoelectric Point: 7.5235
>T161985 WP_032716505.1 NZ_CP055216:c4964819-4964532 [Raoultella ornithinolytica]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRHDRYENGEYRWQTIGLVHGVIVVLVAHSIRFESGTEVIRIIS
ARKADKKERSRYEHG
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRHDRYENGEYRWQTIGLVHGVIVVLVAHSIRFESGTEVIRIIS
ARKADKKERSRYEHG
Download Length: 288 bp
>T161985 NZ_CP071441:c3650674-3650417 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11681.22 Da Isoelectric Point: 9.4429
>AT161985 WP_004857518.1 NZ_CP055216:c4964545-4964240 [Raoultella ornithinolytica]
MSMVKHKRDNPTALTAQREDELKALAKKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIREQNKKS
MSMVKHKRDNPTALTAQREDELKALAKKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIREQNKKS
Download Length: 306 bp
>AT161985 NZ_CP071441:c3650405-3649854 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|