Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2837150..2838753 Replicon chromosome
Accession NZ_CP055216
Organism Raoultella ornithinolytica strain STEFF_15

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag HUZ43_RS13490 Protein ID WP_015584335.1
Coordinates 2837150..2838481 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag HUZ43_RS13495 Protein ID WP_032717448.1
Coordinates 2838481..2838753 (-) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ43_RS13475 (HUZ43_13430) 2833024..2833938 - 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -
HUZ43_RS13480 (HUZ43_13435) 2834038..2835096 - 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
HUZ43_RS13485 (HUZ43_13440) 2835811..2837217 + 1407 WP_239614550.1 glycoside hydrolase family 10 protein -
HUZ43_RS13490 (HUZ43_13445) 2837150..2838481 - 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ43_RS13495 (HUZ43_13450) 2838481..2838753 - 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ43_RS13500 (HUZ43_13455) 2838956..2839510 - 555 WP_004861926.1 RNA polymerase sigma factor -
HUZ43_RS13505 (HUZ43_13460) 2839516..2839941 - 426 WP_032724724.1 hypothetical protein -
HUZ43_RS13510 (HUZ43_13465) 2840074..2841027 - 954 WP_004861921.1 hypothetical protein -
HUZ43_RS13515 (HUZ43_13470) 2841242..2841874 - 633 WP_239613372.1 class I SAM-dependent methyltransferase -
HUZ43_RS13520 (HUZ43_13475) 2841894..2843135 - 1242 WP_015584340.1 sensor domain-containing diguanylate cyclase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-103)

Antitoxin

(14-69)


Sequences


Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T161983 WP_015584335.1 NZ_CP055216:c2838481-2837150 [Raoultella ornithinolytica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

>T161983 NZ_CP071441:3521370-3521720 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT161983 WP_032717448.1 NZ_CP055216:c2838753-2838481 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp

>AT161983 NZ_CP071441:3521125-3521376 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8


Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References