Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871429..872086 Replicon chromosome
Accession NZ_CP055216
Organism Raoultella ornithinolytica strain STEFF_15

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag HUZ43_RS04200 Protein ID WP_004867355.1
Coordinates 871676..872086 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag HUZ43_RS04195 Protein ID WP_004867358.1
Coordinates 871429..871695 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ43_RS04170 (HUZ43_04165) 866564..867997 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
HUZ43_RS04175 (HUZ43_04170) 868117..868845 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
HUZ43_RS04180 (HUZ43_04175) 868895..869206 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
HUZ43_RS04185 (HUZ43_04180) 869368..870027 + 660 WP_004867362.1 hemolysin III family protein -
HUZ43_RS04190 (HUZ43_04185) 870149..871132 - 984 WP_004867359.1 tRNA-modifying protein YgfZ -
HUZ43_RS04195 (HUZ43_04190) 871429..871695 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
HUZ43_RS04200 (HUZ43_04195) 871676..872086 + 411 WP_004867355.1 protein YgfX Toxin
HUZ43_RS04205 (HUZ43_04200) 872094..872615 - 522 WP_004867353.1 flavodoxin FldB -
HUZ43_RS04210 (HUZ43_04205) 872794..873690 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
HUZ43_RS04215 (HUZ43_04210) 873713..874426 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ43_RS04220 (HUZ43_04215) 874432..876165 + 1734 WP_015585785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T161972 WP_004867355.1 NZ_CP055216:871676-872086 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161972 NZ_CP071441:c937892-937789 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT161972 WP_004867358.1 NZ_CP055216:871429-871695 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161972 NZ_CP071441:937751-938022 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References