Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 10116..10759 Replicon plasmid unnamed1
Accession NZ_CP055214
Organism Klebsiella quasipneumoniae strain STEFF_21

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HUZ48_RS24850 Protein ID WP_021312475.1
Coordinates 10343..10759 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A6B7Q5S4
Locus tag HUZ48_RS24845 Protein ID WP_021312476.1
Coordinates 10116..10346 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ48_RS24830 (HUZ48_24760) 6215..7303 + 1089 WP_094716522.1 transcriptional regulator -
HUZ48_RS24835 (HUZ48_24765) 7305..8174 + 870 WP_094716519.1 hypothetical protein -
HUZ48_RS24840 (HUZ48_24770) 8231..9796 - 1566 WP_094716520.1 AAA family ATPase -
HUZ48_RS24845 (HUZ48_24775) 10116..10346 + 231 WP_021312476.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HUZ48_RS24850 (HUZ48_24780) 10343..10759 + 417 WP_021312475.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ48_RS24855 (HUZ48_24785) 10794..11039 + 246 WP_065905238.1 hypothetical protein -
HUZ48_RS24860 (HUZ48_24790) 11103..11321 + 219 WP_021312527.1 hypothetical protein -
HUZ48_RS24865 (HUZ48_24795) 11400..11726 + 327 WP_124989605.1 hypothetical protein -
HUZ48_RS24870 (HUZ48_24800) 11965..12222 + 258 WP_088401882.1 hypothetical protein -
HUZ48_RS24875 (HUZ48_24805) 12222..12797 + 576 WP_065808008.1 hypothetical protein -
HUZ48_RS24880 (HUZ48_24810) 12828..13322 + 495 WP_065808010.1 DNA-binding protein -
HUZ48_RS24885 (HUZ48_24815) 13424..13711 - 288 WP_042938777.1 chorismate mutase -
HUZ48_RS24890 (HUZ48_24820) 13866..14696 - 831 WP_226324355.1 hypothetical protein -
HUZ48_RS24895 (HUZ48_24825) 15022..15288 + 267 Protein_18 ISNCY family transposase -
HUZ48_RS24900 (HUZ48_24830) 15378..15473 + 96 Protein_19 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / aadA2 / qacE / sul1 / mph(A) / aph(3')-Ia / sul2 / floR / catA2 / qnrS1 - 1..160169 160169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15033.44 Da        Isoelectric Point: 7.8915

>T161969 WP_021312475.1 NZ_CP055214:10343-10759 [Klebsiella quasipneumoniae]
VKKTFMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN

Download         Length: 417 bp

>T161969 NZ_CP071441:c330725-330618 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8723.76 Da        Isoelectric Point: 4.3410

>AT161969 WP_021312476.1 NZ_CP055214:10116-10346 [Klebsiella quasipneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL

Download         Length: 231 bp

>AT161969 NZ_CP071441:330772-330838 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6B7Q5S4

References