Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4640140..4640611 Replicon chromosome
Accession NZ_CP055213
Organism Klebsiella quasipneumoniae strain STEFF_21

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HUZ48_RS22305 Protein ID WP_237902294.1
Coordinates 4640140..4640379 (-) Length 80 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C1EW86
Locus tag HUZ48_RS22310 Protein ID WP_023291757.1
Coordinates 4640369..4640611 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ48_RS22295 (4637093) 4637093..4639231 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ48_RS22300 (4639627) 4639627..4640091 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ48_RS22305 (4640140) 4640140..4640379 - 240 WP_237902294.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ48_RS22310 (4640369) 4640369..4640611 - 243 WP_023291757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ48_RS22315 (4640689) 4640689..4642599 - 1911 WP_237902295.1 PRD domain-containing protein -
HUZ48_RS22320 (4642622) 4642622..4643773 - 1152 WP_105491314.1 lactonase family protein -
HUZ48_RS22325 (4643840) 4643840..4644580 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-79)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9190.77 Da        Isoelectric Point: 10.2986

>T161968 WP_237902294.1 NZ_CP055213:c4640379-4640140 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQRVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Download         Length: 240 bp

>T161968 NZ_CP071441:c329654-329547 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9119.58 Da        Isoelectric Point: 4.8146

>AT161968 WP_023291757.1 NZ_CP055213:c4640611-4640369 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Download         Length: 243 bp

>AT161968 NZ_CP071441:329702-329768 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C1EW86

References