Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780086..780743 Replicon chromosome
Accession NZ_CP055213
Organism Klebsiella quasipneumoniae strain STEFF_21

Toxin (Protein)


Gene name cptA Uniprot ID A0A5D1WGJ3
Locus tag HUZ48_RS03865 Protein ID WP_072420599.1
Coordinates 780333..780743 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ48_RS03860 Protein ID WP_002916312.1
Coordinates 780086..780352 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ48_RS03835 (775236) 775236..776669 - 1434 WP_048298253.1 6-phospho-beta-glucosidase -
HUZ48_RS03840 (776788) 776788..777516 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
HUZ48_RS03845 (777567) 777567..777878 + 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
HUZ48_RS03850 (778042) 778042..778701 + 660 WP_008806429.1 hemolysin III family protein -
HUZ48_RS03855 (778857) 778857..779840 - 984 WP_023290969.1 tRNA-modifying protein YgfZ -
HUZ48_RS03860 (780086) 780086..780352 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ48_RS03865 (780333) 780333..780743 + 411 WP_072420599.1 protein YgfX Toxin
HUZ48_RS03870 (780750) 780750..781271 - 522 WP_004205324.1 flavodoxin FldB -
HUZ48_RS03875 (781372) 781372..782268 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ48_RS03880 (782291) 782291..783004 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ48_RS03885 (783010) 783010..784743 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.92 Da        Isoelectric Point: 11.4778

>T161957 WP_072420599.1 NZ_CP055213:780333-780743 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWIINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161957 NZ_CP071439:3904121-3904519 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGTGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161957 WP_002916312.1 NZ_CP055213:780086-780352 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161957 NZ_CP071439:3903825-3904118 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D1WGJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References