Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 201175..201818 Replicon plasmid unnamed1
Accession NZ_CP055211
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HUZ38_RS27045 Protein ID WP_014386165.1
Coordinates 201402..201818 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HUZ38_RS27040 Protein ID WP_032408893.1
Coordinates 201175..201405 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS27015 (HUZ38_26920) 196248..197231 - 984 WP_001471744.1 NAD(P)H-quinone oxidoreductase -
HUZ38_RS27020 (HUZ38_26925) 197250..198398 - 1149 WP_014386168.1 ABC transporter ATP-binding protein -
HUZ38_RS27025 (HUZ38_26930) 198569..199726 - 1158 WP_032408895.1 acetylornithine deacetylase -
HUZ38_RS27030 (HUZ38_26935) 199742..200416 - 675 WP_014386166.1 DUF1028 domain-containing protein -
HUZ38_RS27035 (HUZ38_26940) 200421..200855 - 435 WP_000103648.1 RidA family protein -
HUZ38_RS27040 (HUZ38_26945) 201175..201405 + 231 WP_032408893.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HUZ38_RS27045 (HUZ38_26950) 201402..201818 + 417 WP_014386165.1 PIN domain-containing protein Toxin
HUZ38_RS27050 (HUZ38_26955) 202141..203109 + 969 WP_074422984.1 IS5-like element IS903B family transposase -
HUZ38_RS27055 (HUZ38_26960) 203289..203663 - 375 WP_032408891.1 hypothetical protein -
HUZ38_RS27060 (HUZ38_26965) 203719..204045 - 327 WP_004152639.1 hypothetical protein -
HUZ38_RS27065 (HUZ38_26970) 204042..204770 - 729 WP_014386162.1 plasmid SOS inhibition protein A -
HUZ38_RS27070 (HUZ38_26975) 204767..205198 - 432 WP_014386161.1 conjugation system SOS inhibitor PsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / tet(A) / mph(A) / sul1 / qacE / aadA2 / dfrA12 / blaTEM-1B / blaCTX-M-15 / aac(6')-Ib-cr / blaOXA-1 - 1..223722 223722
- flank IS/Tn - - 202141..203109 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T161951 WP_014386165.1 NZ_CP055211:201402-201818 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

>T161951 NZ_CP071439:3295499-3295672 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT161951 WP_032408893.1 NZ_CP055211:201175-201405 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp

>AT161951 NZ_CP071439:3295175-3295471 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References