Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3636633..3637421 Replicon chromosome
Accession NZ_CP055210
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HUZ38_RS17605 Protein ID WP_085393668.1
Coordinates 3637044..3637421 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HUZ38_RS17600 Protein ID WP_040246534.1
Coordinates 3636633..3636992 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS17555 (3632066) 3632066..3633274 + 1209 WP_213928774.1 IS256 family transposase -
HUZ38_RS17560 (3633434) 3633434..3633736 + 303 WP_085393674.1 hypothetical protein -
HUZ38_RS17565 (3633794) 3633794..3634105 + 312 WP_085393673.1 hypothetical protein -
HUZ38_RS17570 (3634157) 3634157..3634627 + 471 WP_085393672.1 hypothetical protein -
HUZ38_RS17575 (3634701) 3634701..3634922 + 222 WP_085393671.1 hypothetical protein -
HUZ38_RS17580 (3634972) 3634972..3635204 + 233 Protein_3430 DUF905 family protein -
HUZ38_RS17585 (3635407) 3635407..3635877 + 471 WP_085393670.1 antirestriction protein -
HUZ38_RS17590 (3635889) 3635889..3636368 + 480 WP_085393669.1 DNA repair protein RadC -
HUZ38_RS17595 (3636389) 3636389..3636610 + 222 WP_040246532.1 DUF987 domain-containing protein -
HUZ38_RS17600 (3636633) 3636633..3636992 + 360 WP_040246534.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ38_RS17605 (3637044) 3637044..3637421 + 378 WP_085393668.1 TA system toxin CbtA family protein Toxin
HUZ38_RS17610 (3637418) 3637418..3637902 + 485 Protein_3436 DUF5983 family protein -
HUZ38_RS17615 (3637932) 3637932..3638135 + 204 WP_085393666.1 DUF957 domain-containing protein -
HUZ38_RS17620 (3638217) 3638217..3639062 + 846 WP_085393665.1 DUF4942 domain-containing protein -
HUZ38_RS17625 (3639206) 3639206..3640003 + 798 WP_239612320.1 helix-turn-helix transcriptional regulator -
HUZ38_RS17630 (3640317) 3640317..3641428 + 1112 Protein_3440 IS3 family transposase -
HUZ38_RS17635 (3641445) 3641445..3641633 + 189 Protein_3441 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3567814..3648180 80366
- flank IS/Tn - - 3632066..3633274 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13960.80 Da        Isoelectric Point: 5.0715

>T161945 WP_085393668.1 NZ_CP055210:3637044-3637421 [Klebsiella pneumoniae]
MQTQPLSSTQEASPRPSPVDIWQQLLSYLLDRHYGLTLNDTPLGHDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRPGF
SAETQLPLLNSIDILRARKACGLMTRNDYRTVTDITTGKYCGVQP

Download         Length: 378 bp

>T161945 NZ_CP071439:871968-872342 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13035.78 Da        Isoelectric Point: 5.8062

>AT161945 WP_040246534.1 NZ_CP055210:3636633-3636992 [Klebsiella pneumoniae]
MSNEIPAVNHDIAEPWWGLKPTVTPCFGARLVQEGNQVHYLADRASITGQFSEADLRHLDQAFPVLLKQLELMLVSGELN
PHHQHGVTLYAKGLTCEADSLGSHGYIYIAIYPTPAATA

Download         Length: 360 bp

>AT161945 NZ_CP071439:871511-871879 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References