Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3523694..3524210 Replicon chromosome
Accession NZ_CP055210
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HUZ38_RS17140 Protein ID WP_004178374.1
Coordinates 3523926..3524210 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ38_RS17135 Protein ID WP_002886901.1
Coordinates 3523694..3523936 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS17120 (3519722) 3519722..3520462 + 741 WP_002886899.1 KDGP aldolase family protein -
HUZ38_RS17125 (3520529) 3520529..3521683 + 1155 WP_004178372.1 lactonase family protein -
HUZ38_RS17130 (3521706) 3521706..3523616 + 1911 WP_004178373.1 PRD domain-containing protein -
HUZ38_RS17135 (3523694) 3523694..3523936 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ38_RS17140 (3523926) 3523926..3524210 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ38_RS17145 (3524214) 3524214..3524678 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ38_RS17150 (3524919) 3524919..3527057 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ38_RS17155 (3527414) 3527414..3528157 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ38_RS17160 (3528160) 3528160..3528333 - 174 WP_032408826.1 hypothetical protein -
HUZ38_RS17165 (3528418) 3528418..3528726 + 309 WP_022631369.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T161944 WP_004178374.1 NZ_CP055210:3523926-3524210 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T161944 NZ_CP071439:c677243-677140 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT161944 WP_002886901.1 NZ_CP055210:3523694-3523936 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT161944 NZ_CP071439:677102-677373 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References