Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2290395..2291236 Replicon chromosome
Accession NZ_CP055210
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag HUZ38_RS11165 Protein ID WP_000854822.1
Coordinates 2290395..2290778 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag HUZ38_RS11170 Protein ID WP_053271974.1
Coordinates 2290868..2291236 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS11135 (2286019) 2286019..2287860 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
HUZ38_RS11140 (2287960) 2287960..2288466 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
HUZ38_RS11150 (2288765) 2288765..2289610 - 846 WP_001280435.1 DUF4942 domain-containing protein -
HUZ38_RS11155 (2289707) 2289707..2289949 - 243 WP_166635458.1 DUF957 domain-containing protein -
HUZ38_RS11160 (2289916) 2289916..2290404 - 489 WP_001177592.1 DUF5983 family protein -
HUZ38_RS11165 (2290395) 2290395..2290778 - 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HUZ38_RS11170 (2290868) 2290868..2291236 - 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ38_RS11175 (2291316) 2291316..2291537 - 222 WP_000692312.1 DUF987 domain-containing protein -
HUZ38_RS11180 (2291606) 2291606..2292082 - 477 WP_001186747.1 RadC family protein -
HUZ38_RS11185 (2292097) 2292097..2292582 - 486 WP_000214317.1 antirestriction protein -
HUZ38_RS11190 (2292673) 2292673..2293491 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T161940 WP_000854822.1 NZ_CP055210:c2290778-2290395 [Klebsiella pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T161940 NZ_CP071438:4025-4300 [Escherichia coli]
ATGGAACTGAAATGGACTAGCAAGGCGCTCTCTGATTTGGCGCACCTGTATGAATTTCTGGCGCTGGCTAACAAGCCCGC
CGCGGCTCGTGCGGTGCAAGCACTGACACAAGCTCCGACCGTTCTGCTCGCCAACCCGCGTATTGGAGAGCAACTGTTCC
AGTTTGAGCCACGTGAGGTTAGGAGGATTTTGGTGGGGGAGTACGAGGTTCGTTACGAGATCCTAGATTCGATCATCTAC
GTCCTGCGGCTGTGGCATACCCGAGAAAATCGTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT161940 WP_053271974.1 NZ_CP055210:c2291236-2290868 [Klebsiella pneumoniae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT161940 NZ_CP071438:3744-4025 [Escherichia coli]
ATGAAGAGCAACATGACACAAGCAACAACCAAGGTGCTTACTGCACACGTACCAGTACCGATGGCCAATAAAGTTGACCA
GATGGCAGCCCGCCTTGAACGCTCACGGGGTTGGATCATGAAGCAGGCTCTTTCGGCATGGATCGCCCAGGAAGAGGAGC
GTGACCGACTAACCCAAGAGGCGCTGGCAGACGTGAATGCGGGTCGAGTTATCGATCACCAGGCGGTGCAAGCCTGGGCT
GACAGCCTCAGCACTGACCAGCCGCTGTCGGTGCCGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References