Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2143103..2143760 Replicon chromosome
Accession NZ_CP055210
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ38_RS10410 Protein ID WP_002916310.1
Coordinates 2143103..2143513 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ38_RS10415 Protein ID WP_002916312.1
Coordinates 2143494..2143760 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS10390 (2139103) 2139103..2140836 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
HUZ38_RS10395 (2140842) 2140842..2141555 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ38_RS10400 (2141578) 2141578..2142474 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ38_RS10405 (2142575) 2142575..2143096 + 522 WP_004144730.1 flavodoxin FldB -
HUZ38_RS10410 (2143103) 2143103..2143513 - 411 WP_002916310.1 protein YgfX Toxin
HUZ38_RS10415 (2143494) 2143494..2143760 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ38_RS10420 (2144006) 2144006..2144989 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
HUZ38_RS10425 (2145140) 2145140..2145799 - 660 WP_002916317.1 hemolysin III family protein -
HUZ38_RS10430 (2145963) 2145963..2146274 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ38_RS10435 (2146324) 2146324..2147052 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ38_RS10440 (2147171) 2147171..2148604 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161939 WP_002916310.1 NZ_CP055210:c2143513-2143103 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161939 NZ_CP071437:c9519-9238 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161939 WP_002916312.1 NZ_CP055210:c2143760-2143494 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161939 NZ_CP071437:c9760-9509 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References