Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 353044..354632 Replicon chromosome
Accession NZ_CP055210
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HUZ38_RS01725 Protein ID WP_004179815.1
Coordinates 353310..354632 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HUZ38_RS01720 Protein ID WP_004176198.1
Coordinates 353044..353310 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS01695 (348194) 348194..349117 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
HUZ38_RS01700 (349098) 349098..350252 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HUZ38_RS01705 (350598) 350598..351977 + 1380 WP_094932908.1 nucleobase:cation symporter-2 family protein -
HUZ38_RS01710 (351955) 351955..352455 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HUZ38_RS01715 (352452) 352452..352778 + 327 WP_002904788.1 hydroxyisourate hydrolase -
HUZ38_RS01720 (353044) 353044..353310 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ38_RS01725 (353310) 353310..354632 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ38_RS01730 (354649) 354649..355941 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HUZ38_RS01735 (356083) 356083..357087 - 1005 WP_004179822.1 fimbrial protein -
HUZ38_RS01740 (357075) 357075..359576 - 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T161930 WP_004179815.1 NZ_CP055210:353310-354632 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T161930 NZ_CP071436:2567367-2567474 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT161930 WP_004176198.1 NZ_CP055210:353044-353310 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT161930 NZ_CP071436:c2567320-2567254 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References