Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4283842..4284437 Replicon chromosome
Accession NZ_CP055199
Organism Shigella flexneri strain STEFF_3

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HUZ39_RS20960 Protein ID WP_000239579.1
Coordinates 4283842..4284192 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HUZ39_RS20965 Protein ID WP_001223208.1
Coordinates 4284186..4284437 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ39_RS20940 (4279118) 4279118..4280140 - 1023 WP_001296689.1 ABC transporter permease -
HUZ39_RS20945 (4280154) 4280154..4281656 - 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
HUZ39_RS20950 (4281966) 4281966..4282922 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HUZ39_RS20955 (4283232) 4283232..4283762 + 531 WP_000055072.1 inorganic diphosphatase -
HUZ39_RS20960 (4283842) 4283842..4284192 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HUZ39_RS20965 (4284186) 4284186..4284437 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HUZ39_RS20970 (4284649) 4284649..4284990 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HUZ39_RS20975 (4284993) 4284993..4288772 - 3780 WP_000060895.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T161916 WP_000239579.1 NZ_CP055199:c4284192-4283842 [Shigella flexneri]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T161916 NZ_CP071409:831095-831502 [[Pantoea] beijingensis]
GTGGCCCGGTGGCAATCTAATCTGCGCGTGTCTCGCTGCGCAAAGCGCGTCTCACTGGCGCTGCATGGCGGGGCGATTCT
GTTCCTTGTACTGGCGCCCTGGCCGCCTGCTTACATTCCCGTCTGGGTGCTGTTATTTTTGATGGTGCTTGAATGTTGCT
TCAGTCTGCGGCGGATAGAACGTCGGCAGGGGGAAATTTCACTGCTGGCTCCGCGCTTATTATACTGGCGCCAGCAAGAG
TGGCTGATAGTGCGATCTCCCTGGATCTCACCGCAGGGCATTTTACTATCGCTGCGAAGCAGAAAAGGCCAACGTGAATG
CCTCTGGCTAATGCGGGATAGCATGAGTCAAGCTGCCTGGCATTTATTGCGGCAGGGGCTGCTGACCCGATGGTATCGTG
AACGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT161916 WP_001223208.1 NZ_CP055199:c4284437-4284186 [Shigella flexneri]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT161916 NZ_CP071409:830848-831114 [[Pantoea] beijingensis]
ATGGATATAAATAACCGATCACGTATTCACTGGGCATGTCGACGCGGAATGCGCGAACTGGACATCTCAATTATGCCTTT
CTTCGAATATGAATATGATTCGCTTAGCGATGATGATAAGCAGGTATTTATTCGACTACTGGAAAGCGACGATCCCGATC
TCTTCAACTGGATGATGAATCACGGCGAACCAGCCGACCCTGAGCTGAAGCGAATGGTTCAGCTTATTCAAATAAGAAAT
AAACAGCGTGGCCCGGTGGCAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References