161912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2555053..2555691 Replicon chromosome
Accession NZ_CP055199
Organism Shigella flexneri strain STEFF_3

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUZ39_RS12480 Protein ID WP_000813794.1
Coordinates 2555515..2555691 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUZ39_RS12475 Protein ID WP_001270286.1
Coordinates 2555053..2555469 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ39_RS12455 (2550205) 2550205..2551146 - 942 WP_001251315.1 ABC transporter permease -
HUZ39_RS12460 (2551147) 2551147..2552160 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HUZ39_RS12465 (2552178) 2552178..2553323 - 1146 WP_106464763.1 ABC transporter substrate-binding protein -
HUZ39_RS12470 (2553568) 2553568..2554974 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
HUZ39_RS12475 (2555053) 2555053..2555469 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUZ39_RS12480 (2555515) 2555515..2555691 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUZ39_RS12485 (2555913) 2555913..2556143 + 231 WP_000494244.1 YncJ family protein -
HUZ39_RS12490 (2556235) 2556235..2558196 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUZ39_RS12495 (2558269) 2558269..2558805 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HUZ39_RS12500 (2558897) 2558897..2560072 + 1176 WP_001236215.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T161912 WP_000813794.1 NZ_CP055199:c2555691-2555515 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T161912 NZ_CP071405:2016729-2018042 [Pantoea deleyi]
ATGCAGCGGTTAATCGCATGGATGAATGGCGAGCGGGTGGGCGTGCTGACCCGACAGCGCAACGGCGCGCATGCGTTTCA
GTATGACACCGGCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTCTCGATGCCGCTGCAGGTCAAGGCGATCACCT
CTCACGCGGTGATCAATTTCTTCGATAACCTGCTGCCGGACAGCCCGCTGATCCGTGACAGGATCGTGGCGCGTTACCAG
ATTCGCTCACGGCAGCCGTTCGATCTGCTGCAGGAGATAGGCCGGGACAGCGTCGGCGCGACCATGCTGCTGCCGCCCGA
TATGCCGCTGCCCGCTCTGAACGCCCGCTATGAGGTGCTGGATGAATCCCGTCTGGAAAGTGTGCTGTCGGCCTATCAGT
CCGATATTCCACTGGGGATGCTGCGGGAAGAGACCGATTTCCGTATCTCAGTGGCCGGTGCGCAGGAGAAAACCGCGCTG
CTGCTGACCGACGCGGGCTGGAGCATTCCAGCTGGCGCAACGCCCACCTCCCATATCATTAAGCTGCCGATTGGAGAGAT
TAAGCAGCCTGCCGCCACGCTCGACATGCGCGAAAGCGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGCGAACTCG
GTATCGAAGTGCCCCAGGCCACCATAATCCGCGCCGGGACGATGCGCGCGCTGGCCGTCGAACGTTTCGACCGTCGCTGG
TCACGCGATAAAACCCGTCTGATCCGTCTGCCGCAGGAAGATTTCTGTCAGGCGCTGGGGCTGCCGTCCTCGACTAAATA
TGAGTCGGACGGTGGGCCGGGCATTGCGGAGATCATGCAGATACTGATGGGGTCGAGTAACGCCATAGAGGATCGCTACC
GGTTTATGCAGTTTCAGGTGTTTCAGTGGCTGATCGGCGCGACCGATGGCCACGCCAAGAACTTCTCCCTGTTTATCGAG
CGCGGTGGCAGCTACCGTCTGACGCCCTTTTATGATCTGATCTCCGCTTATCCGGTGCTGGGCGGCACCGGGCTGAACAA
ACGCGCCCTGAAACTGGCAATGGGGCTGCGCGCCAGCCGGGGCAAAAAAACGGAGATCGATAAAATCTTTCCGCGCCACT
TTATCGCCACGGCCAGAAGCGTCAGTTTCGATACGGACAGTCTGCAGCAGATTTTCGACTTCTTCGTGCGGGCGTTTCCT
CAGGCGGTTGTGGCGGTGCGCGATATGCTGCCGTCCGGTTTCCCGCAGCACATCGCCGACGCCATTTTCAGCCATTCCCT
GATTATGCTGGAGCGGTTGCGGCATCAGACGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT161912 WP_001270286.1 NZ_CP055199:c2555469-2555053 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT161912 NZ_CP071405:2016481-2016729 [Pantoea deleyi]
ATGATATACAGCCCGCTTCAGCTGGCAAACCGGCTGAAACTGATCCGCCAGCGTAATGGCTGGACCCAGAGTGAACTGGC
AAAGAAGGTTGGTCTGAAACAGGCCACCATTTCTCACTTTGAAAATGCGCCTGACAACACCTCACTGGCCACGCTGTTTA
AACTGCTACAGTCGCTGGAACTGAGTCTGGACGTGCTGGAAAAAGAGGCGGCGACGACGCCCCCGATCGACGATGAGGAT
GCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References