Detailed information of TA system TA161911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2464577..2466165
• Replicon: chromosome
• Accession: NZ_CP055199
• Organism: Shigella flexneri strain STEFF_3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: E0IX85
• Locus tag: HUZ39_RS12090
• Protein ID: WP_001125454.1
• Coordinates: 2464843..2466165 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUZ39_RS12085
• Protein ID: WP_001296726.1
• Coordinates: 2464577..2464843 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ39_RS12085 (2464577)	2464577..2464843	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HUZ39_RS12090 (2464843)	2464843..2466165	+	1323	WP_001125454.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HUZ39_RS12095 (2466477)	2466477..2466685	+	209	Protein_2374	AraC family transcriptional regulator	-
HUZ39_RS12100 (2467117)	2467117..2467680	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
HUZ39_RS12105 (2468041)	2468041..2468751	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2464577..2484490	19913

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49307.90 Da
• Isoelectric Point: 8.8753

>T161911 WP_001125454.1 NZ_CP055199:2464843-2466165 [Shigella flexneri]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T161911 NZ_CP071405:623421-623675 [Pantoea deleyi]
ATGAACAAACGACACCAGAAAACGCTGTCAGATGTGTTCGCCCGGCCGGTTAGCGGTTCAATAAAGTGGAGTGATATTGA
ATCTCTTTTTATCGCTCTCGGTGCGGAGGTTCACGAAAGGGAAGGTTCAAGGATTGCGGTACTGCTGAAAGGGCAAAAGA
AAATATTTCACAGGCCGCACCCCAGACCGACAACTGACAAGGGGGCGGTTAACTCCATCCGGTTATGGCTCGATAGTTTA
GGAATCAGACCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT161911 WP_001296726.1 NZ_CP055199:2464577-2464843 [Shigella flexneri]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT161911 NZ_CP071405:623672-624013 [Pantoea deleyi]
ATGAATAATACACTTAAAATCGACGGCCATCTGGCCGTCATCACCTTTGACCCTGAGATCGAAATGTTTCGTGGGGAGTT
TGTCGGCCTGAACGGCGGAGCTGATTTCTACGCTTATAGCGTCGAAGAGTTGAAAAAAGAGGGTTCAATATCACTGGCGG
TTTTTCTCGAGGAATGCCGCAAGGATGATATCGAACCTTATAAGACATTCAGCGGCAAGGTGACTACCCGCCTGACGCCA
GAACGTCATCAGGCGCTGGCTGTAACTGCTCAGGCGCACGGTGTTTCTATCAATGAGCTGCTCAACGAAGGCGTTGATTT
GGTCATTGAAAAGCACTCGTAG

Structures

Toxin

• AlphaFold DB: E0IX85