Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 17145..17680 Replicon plasmid unnamed3
Accession NZ_CP055197
Organism Shigella flexneri strain STEFF_10

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag HUZ40_RS24905 Protein ID WP_000222771.1
Coordinates 17393..17680 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag HUZ40_RS24900 Protein ID WP_001139206.1
Coordinates 17145..17396 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ40_RS24875 (HUZ40_24705) 13008..13421 + 414 Protein_13 collagenase-like protease -
HUZ40_RS24880 (HUZ40_24710) 13526..13654 - 129 WP_001164804.1 DUF2474 domain-containing protein -
HUZ40_RS24885 (HUZ40_24715) 13654..14664 - 1011 WP_000510495.1 cytochrome d ubiquinol oxidase subunit II -
HUZ40_RS24890 (HUZ40_24720) 14664..16064 - 1401 WP_032185977.1 cytochrome ubiquinol oxidase subunit I -
HUZ40_RS24895 (HUZ40_24725) 16293..16562 - 270 Protein_17 hypothetical protein -
HUZ40_RS24900 (HUZ40_24730) 17145..17396 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUZ40_RS24905 (HUZ40_24735) 17393..17680 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ40_RS24910 18048..18161 - 114 Protein_20 alkaline phosphatase -
HUZ40_RS24915 (HUZ40_24745) 18160..18365 + 206 Protein_21 hypothetical protein -
HUZ40_RS24920 (HUZ40_24750) 18540..22073 - 3534 WP_094317721.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid dfrA14 / tet(A) / blaTEM-1B / aph(6)-Id / aph(3'')-Ib - 1..78847 78847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T161892 WP_000222771.1 NZ_CP055197:17393-17680 [Shigella flexneri]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T161892 NZ_CP071393:4488940-4489158 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT161892 WP_001139206.1 NZ_CP055197:17145-17396 [Shigella flexneri]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT161892 NZ_CP071393:4488539-4488913 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCGACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGATGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCTGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References