Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 4461536..4462580 | Replicon | chromosome |
| Accession | NZ_CP055194 | ||
| Organism | Shigella flexneri strain STEFF_10 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | A0A8I0CFN6 |
| Locus tag | HUZ40_RS21680 | Protein ID | WP_059274466.1 |
| Coordinates | 4461536..4462084 (-) | Length | 183 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A839B6W4 |
| Locus tag | HUZ40_RS21685 | Protein ID | WP_000287252.1 |
| Coordinates | 4462107..4462580 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ40_RS21645 (4456746) | 4456746..4457297 | - | 552 | WP_000515860.1 | protein YmfL | - |
| HUZ40_RS21650 (4457341) | 4457341..4457541 | - | 201 | WP_000649477.1 | YdaS family helix-turn-helix protein | - |
| HUZ40_RS21655 (4457632) | 4457632..4458306 | + | 675 | WP_000859460.1 | LexA family transcriptional regulator | - |
| HUZ40_RS21660 (4458975) | 4458975..4459337 | + | 363 | WP_000135682.1 | protein YfdP | - |
| HUZ40_RS21665 (4459403) | 4459403..4460227 | + | 825 | WP_001753751.1 | DUF2303 family protein | - |
| HUZ40_RS21670 (4460414) | 4460414..4461196 | + | 783 | WP_000610754.1 | hypothetical protein | - |
| HUZ40_RS21675 (4461233) | 4461233..4461502 | + | 270 | WP_001093912.1 | pyocin activator PrtN family protein | - |
| HUZ40_RS21680 (4461536) | 4461536..4462084 | - | 549 | WP_059274466.1 | hypothetical protein | Toxin |
| HUZ40_RS21685 (4462107) | 4462107..4462580 | - | 474 | WP_000287252.1 | DUF4065 domain-containing protein | Antitoxin |
| HUZ40_RS21690 (4462885) | 4462885..4462989 | - | 105 | Protein_4253 | tRNA-dihydrouridine synthase | - |
| HUZ40_RS21695 (4463353) | 4463353..4464375 | - | 1023 | WP_000912594.1 | DUF2713 family protein | - |
| HUZ40_RS21700 (4464693) | 4464693..4465208 | + | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| HUZ40_RS21705 (4465250) | 4465250..4465459 | - | 210 | WP_001030593.1 | CsbD family protein | - |
| HUZ40_RS21710 (4465575) | 4465575..4466900 | - | 1326 | WP_001347655.1 | MATE family efflux transporter DinF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4415785..4468059 | 52274 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 183 a.a. Molecular weight: 20052.43 Da Isoelectric Point: 4.4481
>T161876 WP_059274466.1 NZ_CP055194:c4462084-4461536 [Shigella flexneri]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK
Download Length: 549 bp
>T161876 NZ_CP071385:843000-843410 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 158 a.a. Molecular weight: 17298.80 Da Isoelectric Point: 8.4143
>AT161876 WP_000287252.1 NZ_CP055194:c4462580-4462107 [Shigella flexneri]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
Download Length: 474 bp
>AT161876 NZ_CP071385:842753-843019 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|