161871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3547810..3548428 Replicon chromosome
Accession NZ_CP055194
Organism Shigella flexneri strain STEFF_10

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUZ40_RS17295 Protein ID WP_001291435.1
Coordinates 3548210..3548428 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUZ40_RS17290 Protein ID WP_000344800.1
Coordinates 3547810..3548184 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ40_RS17280 (3542899) 3542899..3544092 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ40_RS17285 (3544115) 3544115..3547264 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HUZ40_RS17290 (3547810) 3547810..3548184 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUZ40_RS17295 (3548210) 3548210..3548428 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HUZ40_RS17300 (3548599) 3548599..3549150 + 552 WP_000102564.1 maltose O-acetyltransferase -
HUZ40_RS17305 (3549266) 3549266..3549736 + 471 WP_000136192.1 YlaC family protein -
HUZ40_RS17310 (3549900) 3549900..3551450 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUZ40_RS17315 (3551492) 3551492..3551845 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HUZ40_RS17325 (3552224) 3552224..3552535 + 312 WP_000409911.1 MGMT family protein -
HUZ40_RS17330 (3552566) 3552566..3553138 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161871 WP_001291435.1 NZ_CP055194:3548210-3548428 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T161871 NZ_CP071383:c3511213-3510797 [Leclercia sp. 4-9-1-25]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCGTGGCGCTCACAGTGGATGTCTCTTTTACTCCACGGGTTGGTTGCGGC
CGCCATTCTGTTAATGCCATGGCCGCTGAGCTATACCCCGCTCTGGCTGCTACTTCTCTCGTTGGTGGTCTTTGACAGCG
TTAGAAGCCAGCGGCGGATCAACGCCCGTCAGGGTGAAATCAAACTGTTTATGGATTCCCGCCTGCGCTGGCAGGGGAAA
GAGTGGGAGATCGTCGGCTCGCCGTGGATGATTAACGCCGGCATGATGCTGCGTCTGCGTGCAAGCGAAGAGCAGCGCTG
CCACCATTTATGGGTATCGGCGGATAGCATGGATGAAGGGGAGTGGCGAGACCTGCGTCGGATGATTGCTCAGCAACAGC
CGACGCAAGGACGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT161871 WP_000344800.1 NZ_CP055194:3547810-3548184 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT161871 NZ_CP071383:c3511460-3511194 [Leclercia sp. 4-9-1-25]
ATGGATATTAATAATAAAGCCCGCATTCACTGGGCATGCCGTCGCGGTATGCGTGAACTCGACATCTCCATCATGCCGTT
CTTCGAACATGAATACGACAGCCTGAGCGATGAAGACAAACAGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCAGATT
TATTCAACTGGCTGATGAATCATGGCGAACCAGCCGACAGCGAGCTGCAACGGATGGTGCTTTTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References