Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1859620..1860455 Replicon chromosome
Accession NZ_CP055194
Organism Shigella flexneri strain STEFF_10

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag HUZ40_RS08960 Protein ID WP_000854752.1
Coordinates 1859620..1859997 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HUZ40_RS08965 Protein ID WP_001278232.1
Coordinates 1860087..1860455 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ40_RS08935 (1855877) 1855877..1857385 + 1509 WP_001474883.1 group II intron reverse transcriptase/maturase -
HUZ40_RS08940 (1857469) 1857469..1857948 + 480 Protein_1752 IS3 family transposase -
HUZ40_RS08945 (1858107) 1858107..1858478 - 372 WP_001295631.1 IS110 family transposase -
HUZ40_RS08950 (1859294) 1859294..1859374 - 81 Protein_1754 hypothetical protein -
HUZ40_RS08955 (1859420) 1859420..1859623 - 204 WP_000761705.1 DUF5983 family protein -
HUZ40_RS08960 (1859620) 1859620..1859997 - 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
HUZ40_RS08965 (1860087) 1860087..1860455 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HUZ40_RS08970 (1860618) 1860618..1860839 - 222 WP_000692318.1 DUF987 domain-containing protein -
HUZ40_RS08975 (1860902) 1860902..1861378 - 477 WP_001186774.1 RadC family protein -
HUZ40_RS08980 (1861394) 1861394..1861879 - 486 WP_000849582.1 antirestriction protein -
HUZ40_RS08985 (1861934) 1861934..1862752 - 819 WP_001234620.1 DUF932 domain-containing protein -
HUZ40_RS08990 (1862852) 1862852..1863085 - 234 WP_001119729.1 DUF905 family protein -
HUZ40_RS08995 (1863164) 1863164..1863619 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T161860 WP_000854752.1 NZ_CP055194:c1859997-1859620 [Shigella flexneri]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T161860 NZ_CP071382:c1995338-1995012 [Geobacter sp. Jerry-YX]
ATGAGGAGAGGCGACCTGGTTCTGGTGGCGACGCCGGGCGACTGCGACAAGCCGCGCCCGGCGCTGATCGTTCAGTCCGA
TCTTTTTTCCGAACATCCGAGTGGCACGATCTGCCTGCTGACCACACACCTCCAGCCGACCCCCCTCTTTCGCCACGAGG
TTACTCCTACCGCCGACAACGGTCTGGTATCGACGTCACAAATTCAGGTGGATAAGATCATGACCGTCCCCAGAGCAAAG
GTCGCTCAAGGCATCGGTCGGCTGACCGACCGGCAAATGAATGAGATAACGAAACTGCTGGCGCTCTGGATCGGTATTGC
GGATTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT161860 WP_001278232.1 NZ_CP055194:c1860455-1860087 [Shigella flexneri]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT161860 NZ_CP071382:c1995547-1995335 [Geobacter sp. Jerry-YX]
ATGCAACATCTAACGGTCAAAGAACGTGTCAAGTCGCATCGAAACAGGCTTAGGGAGGCGGGTTTCAAGCCGGTCCAACT
ATGGGTACCGGACCCCAAAATCCCCGGCTTTGCGGCAGAGTGCCGCCGCCAGTCGCTCATAATCATGAACGATCAGGCTG
AAATGGCCGATCTGGAGCAGCTGGTCGAATTGGCCGACTGGGGGGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References