161854

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 269039..269625 Replicon chromosome
Accession NZ_CP055194
Organism Shigella flexneri strain STEFF_10

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag HUZ40_RS01215 Protein ID WP_042014162.1
Coordinates 269039..269269 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag HUZ40_RS01220 Protein ID WP_000593555.1
Coordinates 269266..269625 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ40_RS01205 (265076) 265076..267811 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
HUZ40_RS01210 (267811) 267811..268935 + 1125 WP_001216257.1 ABC transporter permease -
HUZ40_RS01215 (269039) 269039..269269 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
HUZ40_RS01220 (269266) 269266..269625 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUZ40_RS01225 (269745) 269745..270146 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
HUZ40_RS01230 (270152) 270152..270958 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
HUZ40_RS01235 (270955) 270955..271719 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
HUZ40_RS01240 (271719) 271719..272552 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
HUZ40_RS01245 (272549) 272549..273493 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T161854 WP_042014162.1 NZ_CP055194:269039-269269 [Shigella flexneri]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T161854 NZ_CP071382:205793-206083 [Geobacter sp. Jerry-YX]
ATGGTTGAAATCCGCAAAACCGAGCATTTTGCCAACTGGCTCGACAACTTACGTGATATCCAGGCGAAGGCTCGTGTCCT
TGTAAGGATTGAGCGTCTTGCTTCTGGAAACGCAGGTGACGTCAAGCCTGTGGGTGAAGGTGTCTCGGAAATGCGGATCA
ACTACGGTCCCGGTTATCGAGTTTATTTTATTCAACGCGGCAGCGAATTGATCATCCTGTTGGCCGGTGGCGACAAGAGC
AGCCAGTCTCGGGATATCAAGGCAGCTGTCCGGCTTGCTCAGAACCTATAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT161854 WP_000593555.1 NZ_CP055194:269266-269625 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT161854 NZ_CP071382:206093-206389 [Geobacter sp. Jerry-YX]
ATGGCCAAGACTGCTACCAGTCGTTATGATGTCGCGGAACATCTCCGTACTCCGGAAGAAATGGCGGCCTATCTTGAAGC
ATCGCTCGAAGAGGCTAATGGTGATGCAGCTTTCATTGCCAAAGCCCTCGGCGACATAGCCCGAGCCAAAGGGATGTCTC
AAGTGGCGCGCGATGCCGGTCTTTCTCGTGAAAGTCTTTACAAGGCACTTTCAGGTGAGCGGGTGCCTGGTTTTGATACT
ATTTTAAAAGTCGTTTCAGCACTGGGACTCAAACTTCATGCAGAGGCCGCTCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References