Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2640176..2641764 Replicon chromosome
Accession NZ_CP055186
Organism Klebsiella pneumoniae strain STEFF_14

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HUZ42_RS12950 Protein ID WP_004179815.1
Coordinates 2640176..2641498 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HUZ42_RS12955 Protein ID WP_004176198.1
Coordinates 2641498..2641764 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ42_RS12935 (2635232) 2635232..2637733 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
HUZ42_RS12940 (2637721) 2637721..2638725 + 1005 WP_004179822.1 fimbrial protein -
HUZ42_RS12945 (2638867) 2638867..2640159 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HUZ42_RS12950 (2640176) 2640176..2641498 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ42_RS12955 (2641498) 2641498..2641764 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ42_RS12960 (2642030) 2642030..2642356 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HUZ42_RS12965 (2642353) 2642353..2642853 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HUZ42_RS12970 (2642831) 2642831..2644210 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
HUZ42_RS12975 (2644556) 2644556..2645710 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HUZ42_RS12980 (2645691) 2645691..2646614 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T161846 WP_004179815.1 NZ_CP055186:c2641498-2640176 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T161846 NZ_CP071375:c3058174-3058019 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAATCTGAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT161846 WP_004176198.1 NZ_CP055186:c2641764-2641498 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT161846 NZ_CP071375:3058186-3058244 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References