Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808455..809112 Replicon chromosome
Accession NZ_CP055186
Organism Klebsiella pneumoniae strain STEFF_14

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ42_RS03995 Protein ID WP_002916310.1
Coordinates 808702..809112 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ42_RS03990 Protein ID WP_002916312.1
Coordinates 808455..808721 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ42_RS03965 (803611) 803611..805044 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
HUZ42_RS03970 (805163) 805163..805891 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ42_RS03975 (805941) 805941..806252 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ42_RS03980 (806416) 806416..807075 + 660 WP_002916317.1 hemolysin III family protein -
HUZ42_RS03985 (807226) 807226..808209 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
HUZ42_RS03990 (808455) 808455..808721 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ42_RS03995 (808702) 808702..809112 + 411 WP_002916310.1 protein YgfX Toxin
HUZ42_RS04000 (809119) 809119..809640 - 522 WP_064159432.1 flavodoxin FldB -
HUZ42_RS04005 (809741) 809741..810637 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ42_RS04010 (810660) 810660..811373 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ42_RS04015 (811379) 811379..813112 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161837 WP_002916310.1 NZ_CP055186:808702-809112 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161837 NZ_CP071375:c1011822-1011544 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAATGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAGG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGTGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161837 WP_002916312.1 NZ_CP055186:808455-808721 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161837 NZ_CP071375:c1012085-1011825 [Escherichia coli]
ATGGCTGCAAATGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References