Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 478..1000 Replicon plasmid unnamed1
Accession NZ_CP055185
Organism Shigella flexneri strain STEFF_16

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HUZ44_RS22790 Protein ID WP_000220560.1
Coordinates 478..759 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HUZ44_RS22795 Protein ID WP_000121743.1
Coordinates 749..1000 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ44_RS22785 (HUZ44_22645) 9..332 - 324 WP_001181903.1 hypothetical protein -
HUZ44_RS22790 (HUZ44_22650) 478..759 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ44_RS22795 (HUZ44_22655) 749..1000 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HUZ44_RS22800 (HUZ44_22660) 2256..3092 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
HUZ44_RS22805 (HUZ44_22665) 3132..3578 + 447 WP_001074386.1 hypothetical protein -
HUZ44_RS22810 (HUZ44_22675) 3715..4068 + 354 WP_000876434.1 DNA distortion polypeptide 3 -
HUZ44_RS22815 (HUZ44_22680) 4128..5096 - 969 WP_077249520.1 IS5-like element IS903B family transposase -
HUZ44_RS22820 (HUZ44_22685) 5098..5391 - 294 WP_015060510.1 hypothetical protein -
HUZ44_RS22825 (HUZ44_22690) 5407..5637 - 231 WP_000051064.1 plasmid partition protein ParG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-176 / floR / tet(A) / qnrS1 / dfrA14 / aph(3')-Ia - 1..46569 46569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T161834 WP_000220560.1 NZ_CP055185:c759-478 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T161834 NZ_CP071326:c1039066-1038536 [Photobacterium ganghwense]
GTGAGCTGGTCAAAAACATTTGTTGAACTGGACAAGCATGTTCACGATCGAGCTTCATTTGACTGCGGTGAAGCTGAGTT
AAACACATTCATTCAGACTCAGGCATCAAAACATATGCAGGCAGGTATCAGCCGTACCATGGTGTTACCTGCCAGCCTGC
CGTTGCTCAATCAAAAATGGCCAATTTGCGCCTTCTATAGTGTCGCCCCGAGTTCTATTCGGCGTGAGACCTTGCCAGTA
TCATTGGCTAAAAAGCTACCTAATTATCCCATTCCGGTTTTCCTGCTTGCGCAATTGGCGGTTCACCGGGAATATCACGG
CCATGGTTTGGGTAAAGTTAGCCTGATTCGGGCGTTGAAATACCTGTGGGAAGTGAATGCCCATATGCGGGCTTATGCGA
TAGTGGTGGATTGCCTGACGCCTGCGGCGGAAGCGTTTTACACTAAGTACGGTTTTCAGGTGTTGTGTGATCACAATGGC
CGAACCCGAATGTTTATTCCGATGAAAACCGTTGGTCAGCTTTTTAGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT161834 WP_000121743.1 NZ_CP055185:c1000-749 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT161834 NZ_CP071326:c1039332-1039063 [Photobacterium ganghwense]
ATGGCAACAGCGCGTTTAGACCTGCGGTTAGACGAAGAGATTAAAGCCAAAGCAGAAAAAGCATCCGCTTTGCTGGGGTT
GAAGAGTCTGACCGAATATGTTGTCCGGCTGATGGATGAAGATGCAACGCAGGTTATTGCTCAACATGAAAGCATGACGG
TACAAAATGATGTATTTGATCGCTTTATGGACGCCTGTGATAAAGCAGAAGCGCCTAATCAGGCTCTGCGCGATGCCGCG
GCATTCACGGAAGAGAATGGATTCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References