161816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846731..847385 Replicon chromosome
Accession NZ_CP055184
Organism Shigella flexneri strain STEFF_16

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag HUZ44_RS04125 Protein ID WP_000244772.1
Coordinates 846978..847385 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HUZ44_RS04120 Protein ID WP_000354046.1
Coordinates 846731..846997 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ44_RS04095 (842019) 842019..842762 + 744 WP_239618407.1 SDR family oxidoreductase -
HUZ44_RS04100 (842819) 842819..844252 - 1434 WP_001387034.1 6-phospho-beta-glucosidase BglA -
HUZ44_RS04105 (844297) 844297..844608 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HUZ44_RS04110 (844772) 844772..845431 + 660 WP_000250274.1 hemolysin III family protein -
HUZ44_RS04115 (845508) 845508..846488 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HUZ44_RS04120 (846731) 846731..846997 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HUZ44_RS04125 (846978) 846978..847385 + 408 WP_000244772.1 protein YgfX Toxin
HUZ44_RS04130 (847425) 847425..847946 - 522 WP_239618410.1 flavodoxin FldB -
HUZ44_RS04135 (848058) 848058..848954 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HUZ44_RS04140 (848979) 848979..849689 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ44_RS04145 (849695) 849695..851428 + 1734 WP_000813223.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T161816 WP_000244772.1 NZ_CP055184:846978-847385 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T161816 NZ_CP071320:c3027530-3027434 [Serratia ureilytica]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT161816 WP_000354046.1 NZ_CP055184:846731-846997 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161816 NZ_CP071320:3027434-3027574 [Serratia ureilytica]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTATAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References