Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 30338..30860 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP055183 | ||
| Organism | Shigella flexneri strain STEFF_17 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G3CAN5 |
| Locus tag | HUZ45_RS23170 | Protein ID | WP_000220560.1 |
| Coordinates | 30579..30860 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | HUZ45_RS23165 | Protein ID | WP_000121743.1 |
| Coordinates | 30338..30589 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ45_RS23135 (HUZ45_22995) | 25701..25931 | + | 231 | WP_000051064.1 | plasmid partition protein ParG | - |
| HUZ45_RS23140 (HUZ45_23000) | 25947..26240 | + | 294 | WP_015060510.1 | hypothetical protein | - |
| HUZ45_RS23145 (HUZ45_23005) | 26242..27210 | + | 969 | WP_077249520.1 | IS5-like element IS903B family transposase | - |
| HUZ45_RS23150 (HUZ45_23010) | 27270..27623 | - | 354 | WP_000876434.1 | DNA distortion polypeptide 3 | - |
| HUZ45_RS23155 (HUZ45_23020) | 27760..28206 | - | 447 | WP_001074386.1 | hypothetical protein | - |
| HUZ45_RS23160 (HUZ45_23025) | 28246..29082 | - | 837 | WP_001050931.1 | RepB family plasmid replication initiator protein | - |
| HUZ45_RS23165 (HUZ45_23030) | 30338..30589 | + | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| HUZ45_RS23170 (HUZ45_23035) | 30579..30860 | + | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HUZ45_RS23175 (HUZ45_23040) | 31006..31329 | + | 324 | WP_001181903.1 | hypothetical protein | - |
| HUZ45_RS23180 (HUZ45_23045) | 31374..31619 | + | 246 | WP_000356546.1 | hypothetical protein | - |
| HUZ45_RS23185 (HUZ45_23050) | 31609..31824 | + | 216 | WP_001180116.1 | hypothetical protein | - |
| HUZ45_RS23190 (HUZ45_23055) | 31917..32246 | + | 330 | WP_000866648.1 | hypothetical protein | - |
| HUZ45_RS23195 (HUZ45_23060) | 32533..32682 | + | 150 | WP_000003880.1 | hypothetical protein | - |
| HUZ45_RS23200 (HUZ45_23065) | 32695..32967 | + | 273 | WP_000160399.1 | hypothetical protein | - |
| HUZ45_RS23205 (HUZ45_23070) | 33294..33839 | + | 546 | WP_038976855.1 | DNA distortion polypeptide 1 | - |
| HUZ45_RS23210 (HUZ45_23075) | 33842..34999 | + | 1158 | WP_000538023.1 | DNA distortion polypeptide 2 | - |
| HUZ45_RS23215 (HUZ45_23080) | 35360..35851 | + | 492 | WP_000872475.1 | transcription termination/antitermination NusG family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3')-Ia / qnrS1 | - | 1..35925 | 35925 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T161814 WP_000220560.1 NZ_CP055183:30579-30860 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T161814 NZ_CP071320:c911782-911438 [Serratia ureilytica]
ATGTGGCAAGTGGTGACCGTCGAACGATTCGACGACTGGTTTTTGGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGAAGCGGCCC
GGCAGTTGAAGGAGTTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCTGCCATGGAATTTTC
ACATTATCTGGCAACCCGGAGGTAG
ATGTGGCAAGTGGTGACCGTCGAACGATTCGACGACTGGTTTTTGGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGAAGCGGCCC
GGCAGTTGAAGGAGTTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCTGCCATGGAATTTTC
ACATTATCTGGCAACCCGGAGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT161814 WP_000121743.1 NZ_CP055183:30338-30589 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT161814 NZ_CP071320:c911432-911130 [Serratia ureilytica]
ATGGCCAAACCGTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAACTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGTATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA
ATGGCCAAACCGTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAACTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGTATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G3CAN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |