Detailed information of TA system TA161810

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2814016..2814850
• Replicon: chromosome
• Accession: NZ_CP055181
• Organism: Shigella flexneri strain STEFF_17

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: W0S379
• Locus tag: HUZ45_RS13800
• Protein ID: WP_000854808.1
• Coordinates: 2814016..2814393 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HUZ45_RS13805
• Protein ID: WP_089616088.1
• Coordinates: 2814482..2814850 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ45_RS13760 (2809023)	2809023..2809514	-	492	WP_219383551.1	DUF1097 domain-containing protein	-
HUZ45_RS13765 (2809616)	2809616..2810170	-	555	WP_001001902.1	molecular chaperone YcdY	-
HUZ45_RS13770 (2810194)	2810194..2810931	-	738	WP_000283664.1	zinc-binding phosphatase	-
HUZ45_RS13775 (2810986)	2810986..2811924	-	939	WP_000351315.1	glyoxylate/hydroxypyruvate reductase GhrA	-
HUZ45_RS13785 (2812395)	2812395..2813237	-	843	WP_063101836.1	DUF4942 domain-containing protein	-
HUZ45_RS13790 (2813322)	2813322..2813519	-	198	WP_029396577.1	DUF957 domain-containing protein	-
HUZ45_RS13795 (2813531)	2813531..2814019	-	489	WP_068862750.1	DUF5983 family protein	-
HUZ45_RS13800 (2814016)	2814016..2814393	-	378	WP_000854808.1	type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA	Toxin
HUZ45_RS13805 (2814482)	2814482..2814850	-	369	WP_089616088.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
HUZ45_RS13810 (2814900)	2814900..2815544	-	645	WP_152914933.1	antitoxin of toxin-antitoxin stability system	-
HUZ45_RS13815 (2815559)	2815559..2815780	-	222	WP_000692353.1	DUF987 domain-containing protein	-
HUZ45_RS13820 (2815849)	2815849..2816325	-	477	WP_001384029.1	RadC family protein	-
HUZ45_RS13825 (2816340)	2816340..2816825	-	486	WP_000214317.1	antirestriction protein	-
HUZ45_RS13830 (2816916)	2816916..2817734	-	819	WP_001234702.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13909.93 Da
• Isoelectric Point: 7.9085

>T161810 WP_000854808.1 NZ_CP055181:c2814393-2814016 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T161810 NZ_CP071319:2746333-2746620 [Acinetobacter indicus]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACGGCAAG
CCTTGTTTTTGATGATCCACTGAGGATCTCAATTCAGGACAGACATACCGATGGTGAAGAACGTTGGCAGACCATTGGGA
AAGTAAAAGGCGTACTAATGCTCTTAGTAGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTCACTAAGGCGGAGCGAGATAGATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13679.49 Da
• Isoelectric Point: 6.7380

>AT161810 WP_089616088.1 NZ_CP055181:c2814850-2814482 [Shigella flexneri]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGWFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Nucleotide

• Length: 369 bp

>AT161810 NZ_CP071319:2746607-2746948 [Acinetobacter indicus]
ATGAGCATGGTTAGATACTCACGTAAAGAACTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAAGGGACGGTTCCTGATGATCAGCTAGATCTCTCAGATATTCCTGAAATTACCGACTGGAGCAATGCTGTACGCC
ATAATCAATTCTATCGCCCAGTGAAGCAACAGACTTCCATCCGTTTAGATGCTGATGTACTTGCATGGTTTAAAGCTCAA
GGTAAAGGCTATCAGACACGTATGAATGAAATCTTGCGGGATGCCATGCTAAAAGAATTAAAAATCATCAATAAAAATGG
GAGCTTAAGCTCCCATTTTTGA

Structures

Toxin

• AlphaFold DB: W0S379