Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2386709..2387347 Replicon chromosome
Accession NZ_CP055181
Organism Shigella flexneri strain STEFF_17

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUZ45_RS11580 Protein ID WP_000813794.1
Coordinates 2387171..2387347 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUZ45_RS11575 Protein ID WP_001270286.1
Coordinates 2386709..2387125 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ45_RS11555 (2381861) 2381861..2382802 - 942 WP_152914928.1 ABC transporter permease -
HUZ45_RS11560 (2382803) 2382803..2383816 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
HUZ45_RS11565 (2383834) 2383834..2384979 - 1146 WP_000047418.1 ABC transporter substrate-binding protein -
HUZ45_RS11570 (2385224) 2385224..2386630 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HUZ45_RS11575 (2386709) 2386709..2387125 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUZ45_RS11580 (2387171) 2387171..2387347 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUZ45_RS11585 (2387569) 2387569..2387799 + 231 WP_000494244.1 YncJ family protein -
HUZ45_RS11590 (2387891) 2387891..2389852 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUZ45_RS11595 (2389925) 2389925..2390461 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HUZ45_RS11600 (2390553) 2390553..2391728 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T161809 WP_000813794.1 NZ_CP055181:c2387347-2387171 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T161809 NZ_CP071319:c1254391-1253999 [Acinetobacter indicus]
ATGTCCACGGCTAAGCGCGACTTTCAGCTGAAACCGAGCCGTCTGGCGCTGCTGTTTCAGCTGAGCCTGCTGATTCTATT
TTCTGTTTTAAGTTTTCAATTATTACATCCGCTGCTTTGGCTGCTAGGTCTGCTCCTGGCGGCTGTCAGTTATTACGGGT
TTCAGCGACGCTCCCAATTAACCGCCTTGGCGCATTTAGATGGGGCAGAGTGGAGTCTGCAGTTTAATTCTGGCTCCAAG
ATTCAACGCGGTCTGCTCGAGCATATTCTGGATCATCAGCTGTATCTGGTGCTGTATTTTCATCATGCACCGGTCAAATC
TGCAGTCATCTGGCGTGACCAAGTTTCGTTTGCAGAGTGGAAAGCCTTAAAAACATTGGCAAAAACCATCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT161809 WP_001270286.1 NZ_CP055181:c2387125-2386709 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT161809 NZ_CP071319:c1254635-1254378 [Acinetobacter indicus]
ATGAGTGAAGACATTAGCTTAGAAGAGCGTAAAGTGATTTATCGTGCCCGTCGCGGTTTAAAGGAAATTGATGTCTACTT
TGATCCTTATGTGAAAAACTATTATTTAACCGCTGATCCGGAAGAAAAAGCCACGTTTGCGGCGCTGGTTGAACAGGAAG
ATCCGGATTTACTGGACTGGTTTATGGAAGTGTCTGAACCGCCACGCCCGGAAATGCGCGAGCTGATCCGTAAATTAAAA
CACTATGTCCACGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References