Detailed information of TA system TA161796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 828995..829593
• Replicon: chromosome
• Accession: NZ_CP055181
• Organism: Shigella flexneri strain STEFF_17

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A8T6PRV3
• Locus tag: HUZ45_RS04090
• Protein ID: WP_053291281.1
• Coordinates: 829216..829593 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: L4J1C0
• Locus tag: HUZ45_RS04085
• Protein ID: WP_001603498.1
• Coordinates: 828995..829216 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ45_RS04070 (824605)	824605..825285	+	681	WP_063100857.1	fimbrial assembly chaperone	-
HUZ45_RS04075 (825303)	825303..827789	+	2487	WP_111970038.1	fimbrial biogenesis outer membrane usher protein	-
HUZ45_RS04080 (827800)	827800..828810	+	1011	WP_239638151.1	fimbrial protein	-
HUZ45_RS04085 (828995)	828995..829216	+	222	WP_001603498.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUZ45_RS04090 (829216)	829216..829593	+	378	WP_053291281.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HUZ45_RS04095 (829703)	829703..829918	-	216	Protein_806	transposase	-
HUZ45_RS04100 (830104)	830104..831366	-	1263	WP_239638152.1	integrase arm-type DNA-binding domain-containing protein	-
HUZ45_RS04110 (831745)	831745..832452	-	708	WP_000234526.1	DUF554 domain-containing protein	-
HUZ45_RS04115 (832605)	832605..832688	+	84	WP_212734243.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / tviB / tviC	749738..837572	87834
	-	flank	IS/Tn	-	-	829637..829918	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (4-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13487.28 Da
• Isoelectric Point: 6.2257

>T161796 WP_053291281.1 NZ_CP055181:829216-829593 [Shigella flexneri]
MRHISPEELIAIHDANISRYGGLPGMPDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Nucleotide

• Length: 378 bp

>T161796 NZ_CP071305:1088741-1089007 [Streptococcus suis]
TTGAGTTATAAGGTCATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATAGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8190.24 Da
• Isoelectric Point: 6.3159

>AT161796 WP_001603498.1 NZ_CP055181:828995-829216 [Shigella flexneri]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Nucleotide

• Length: 222 bp

>AT161796 NZ_CP071305:1088512-1088751 [Streptococcus suis]
ATGGCAGCTATTACTTTAAAGGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAGGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAAACACTTGAAGCCCTTGAAGATGAATACGATGCGCGTGTGGCAGACATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: L4J1C0