Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 53540..54450 Replicon plasmid unnamed1
Accession NZ_CP055175
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag HUZ47_RS26260 Protein ID WP_004144067.1
Coordinates 53980..54450 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag HUZ47_RS26255 Protein ID WP_023287184.1
Coordinates 53540..53983 (+) Length 148 a.a.

Genomic Context

HUZ47_RS26235HUZ47_RS26240HUZ47_RS26245HUZ47_RS26250HUZ47_RS26255HUZ47_RS26260HUZ47_RS26265HUZ47_RS26270HUZ47_RS26280HUZ47_RS26275
Location: 48956..49705 (750 bp)
Type: Others
Protein ID: Protein_53
Location: 49734..50702 (969 bp)
Type: Others
Protein ID: WP_077254762.1
Location: 50898..52244 (1347 bp)
Type: Others
Protein ID: WP_225517490.1
Location: 52297..53439 (1143 bp)
Type: Others
Protein ID: Protein_56
Location: 53540..53983 (444 bp)
Type: Antitoxin
Protein ID: WP_023287184.1
Location: 53980..54450 (471 bp)
Type: Toxin
Protein ID: WP_004144067.1
Location: 54537..55532 (996 bp)
Type: Others
Protein ID: WP_180334945.1
Location: 55534..56502 (969 bp)
Type: Others
Protein ID: WP_072096747.1
Location: 57256..58224 (969 bp)
Type: Others
Protein ID: WP_074423483.1
Location: 56691..56951 (261 bp)
Type: Others
Protein ID: WP_017901409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HUZ47_RS26235 (HUZ47_26200)48956..49705+750Protein_53IS5 family transposase-
HUZ47_RS26240 (HUZ47_26205)49734..50702+969WP_077254762.1IS5 family transposase-
HUZ47_RS26245 (HUZ47_26210)50898..52244+1347WP_225517490.1ThiF family adenylyltransferase-
HUZ47_RS26250 (HUZ47_26215)52297..53439+1143Protein_56translesion error-prone DNA polymerase V subunit UmuC-
HUZ47_RS26255 (HUZ47_26220)53540..53983+444WP_023287184.1DUF2384 domain-containing proteinAntitoxin
HUZ47_RS26260 (HUZ47_26225)53980..54450+471WP_004144067.1RES family NAD+ phosphorylaseToxin
HUZ47_RS26265 (HUZ47_26230)54537..55532+996WP_180334945.1IS5 family transposase-
HUZ47_RS26270 (HUZ47_26235)55534..56502+969WP_072096747.1IS5 family transposase-
HUZ47_RS26275 (HUZ47_26240)56691..56951-261WP_017901409.1hypothetical protein-
HUZ47_RS26280 (HUZ47_26245)57256..58224+969WP_074423483.1IS5 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaph(3')-Ia / mph(A) / sul1 / qacE / aadA2 / dfrA12 / tet(D) / aph(6)-Id / aph(3'')-Ib / catA1 / sul2-1..233421233421
-insideIScluster/Tn--46812..5822411412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T161756 WP_004144067.1 NZ_CP055175:53980-54450 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T161756 NZ_CP071263:3395291-3395464 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT161756 WP_023287184.1 NZ_CP055175:53540-53983 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT161756 NZ_CP071263:3394967-3395263 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A384IED8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6A8PHD0

References