Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5303521..5304146 Replicon chromosome
Accession NZ_CP055174
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag HUZ47_RS25605 Protein ID WP_002882817.1
Coordinates 5303521..5303904 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag HUZ47_RS25610 Protein ID WP_004150355.1
Coordinates 5303904..5304146 (-) Length 81 a.a.

Genomic Context

HUZ47_RS25590HUZ47_RS25595HUZ47_RS25600HUZ47_RS25615HUZ47_RS25605HUZ47_RS25610HUZ47_RS25620HUZ47_RS25625HUZ47_RS25630HUZ47_RS25635
Location: 5300887..5301789 (903 bp)
Type: Others
Protein ID: WP_002882822.1
Location: 5301786..5302421 (636 bp)
Type: Others
Protein ID: WP_002882818.1
Location: 5302418..5303347 (930 bp)
Type: Others
Protein ID: WP_004150358.1
Location: 5304351..5305268 (918 bp)
Type: Others
Protein ID: WP_004895173.1
Location: 5303521..5303904 (384 bp)
Type: Toxin
Protein ID: WP_002882817.1
Location: 5303904..5304146 (243 bp)
Type: Antitoxin
Protein ID: WP_004150355.1
Location: 5305282..5306223 (942 bp)
Type: Others
Protein ID: WP_004178031.1
Location: 5306268..5306705 (438 bp)
Type: Others
Protein ID: WP_002882809.1
Location: 5306702..5307562 (861 bp)
Type: Others
Protein ID: WP_004146232.1
Location: 5307556..5308155 (600 bp)
Type: Others
Protein ID: WP_004151865.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HUZ47_RS25590 (HUZ47_25555)5300887..5301789+903WP_002882822.1formate dehydrogenase subunit beta-
HUZ47_RS25595 (HUZ47_25560)5301786..5302421+636WP_002882818.1formate dehydrogenase cytochrome b556 subunit-
HUZ47_RS25600 (HUZ47_25565)5302418..5303347+930WP_004150358.1formate dehydrogenase accessory protein FdhE-
HUZ47_RS25605 (HUZ47_25570)5303521..5303904-384WP_002882817.1type II toxin-antitoxin system VapC family toxinToxin
HUZ47_RS25610 (HUZ47_25575)5303904..5304146-243WP_004150355.1CopG family transcriptional regulatorAntitoxin
HUZ47_RS25615 (HUZ47_25580)5304351..5305268+918WP_004895173.1alpha/beta hydrolase-
HUZ47_RS25620 (HUZ47_25585)5305282..5306223-942WP_004178031.1fatty acid biosynthesis protein FabY-
HUZ47_RS25625 (HUZ47_25590)5306268..5306705-438WP_002882809.1D-aminoacyl-tRNA deacylase-
HUZ47_RS25630 (HUZ47_25595)5306702..5307562-861WP_004146232.1virulence factor BrkB family protein-
HUZ47_RS25635 (HUZ47_25600)5307556..5308155-600WP_004151865.1glucose-1-phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T161755 WP_002882817.1 NZ_CP055174:c5303904-5303521 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T161755 NZ_CP071263:c2767760-2767575 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT161755 WP_004150355.1 NZ_CP055174:c5304146-5303904 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT161755 NZ_CP071263:c2767558-2767148 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACTACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTATGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GPK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GGU9

References