Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4737120..4737823 Replicon chromosome
Accession NZ_CP055174
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HUZ47_RS22930 Protein ID WP_017880111.1
Coordinates 4737120..4737461 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HUZ47_RS22935 Protein ID WP_050131139.1
Coordinates 4737482..4737823 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ47_RS22905 (HUZ47_22870) 4733691..4734818 + 1128 WP_023325431.1 PAAR domain-containing protein -
HUZ47_RS22910 (HUZ47_22875) 4734808..4735071 + 264 WP_004192273.1 hypothetical protein -
HUZ47_RS22915 (HUZ47_22880) 4735217..4735351 + 135 Protein_4497 transposase -
HUZ47_RS22920 (HUZ47_22885) 4735364..4735474 - 111 Protein_4498 DUF4102 domain-containing protein -
HUZ47_RS22925 (HUZ47_22890) 4735849..4736856 - 1008 WP_017880110.1 restriction endonuclease -
HUZ47_RS22930 (HUZ47_22895) 4737120..4737461 - 342 WP_017880111.1 TA system toxin CbtA family protein Toxin
HUZ47_RS22935 (HUZ47_22900) 4737482..4737823 - 342 WP_050131139.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ47_RS22940 (HUZ47_22905) 4737834..4738376 - 543 WP_017880113.1 DNA repair protein RadC -
HUZ47_RS22945 (HUZ47_22910) 4738389..4738832 - 444 WP_017880114.1 antirestriction protein -
HUZ47_RS22950 (HUZ47_22915) 4738863..4739684 - 822 WP_017880115.1 DUF932 domain-containing protein -
HUZ47_RS22955 (HUZ47_22920) 4739805..4740278 - 474 WP_031280324.1 hypothetical protein -
HUZ47_RS22960 (HUZ47_22925) 4740350..4740802 - 453 WP_031280325.1 hypothetical protein -
HUZ47_RS22965 (HUZ47_22930) 4740838..4741554 - 717 WP_239612758.1 WYL domain-containing protein -
HUZ47_RS22970 (HUZ47_22935) 4741798..4742673 - 876 WP_017880120.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4729564..4777328 47764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12811.73 Da        Isoelectric Point: 8.4941

>T161753 WP_017880111.1 NZ_CP055174:c4737461-4737120 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T161753 NZ_CP071263:c2712812-2712705 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGATCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTCGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12821.45 Da        Isoelectric Point: 6.3148

>AT161753 WP_050131139.1 NZ_CP055174:c4737823-4737482 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp

>AT161753 NZ_CP071263:2712870-2712924 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References