Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
| Location | 4701593..4702403 | Replicon | chromosome |
| Accession | NZ_CP055174 | ||
| Organism | Klebsiella pneumoniae strain STEFF_19 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | A0A060VJ83 |
| Locus tag | HUZ47_RS22760 | Protein ID | WP_004178461.1 |
| Coordinates | 4701593..4702126 (-) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | J2E9Q7 |
| Locus tag | HUZ47_RS22765 | Protein ID | WP_002887278.1 |
| Coordinates | 4702137..4702403 (-) | Length | 89 a.a. |
Genomic Context
Location: 4700424..4701545 (1122 bp)
Type: Others
Protein ID: WP_002887282.1
Type: Others
Protein ID: WP_002887282.1
Location: 4704784..4706169 (1386 bp)
Type: Others
Protein ID: WP_004894567.1
Type: Others
Protein ID: WP_004894567.1
Location: 4706187..4706531 (345 bp)
Type: Others
Protein ID: WP_004894569.1
Type: Others
Protein ID: WP_004894569.1
Location: 4701593..4702126 (534 bp)
Type: Toxin
Protein ID: WP_004178461.1
Type: Toxin
Protein ID: WP_004178461.1
Location: 4702137..4702403 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 4702506..4703939 (1434 bp)
Type: Others
Protein ID: WP_004894565.1
Type: Others
Protein ID: WP_004894565.1
Location: 4703929..4704612 (684 bp)
Type: Others
Protein ID: WP_002887273.1
Type: Others
Protein ID: WP_002887273.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ47_RS22755 (HUZ47_22720) | 4700424..4701545 | + | 1122 | WP_002887282.1 | cupin domain-containing protein | - |
| HUZ47_RS22760 (HUZ47_22725) | 4701593..4702126 | - | 534 | WP_004178461.1 | type II toxin-antitoxin system toxin KacT | Toxin |
| HUZ47_RS22765 (HUZ47_22730) | 4702137..4702403 | - | 267 | WP_002887278.1 | type II toxin-antitoxin system antitoxin KacA | Antitoxin |
| HUZ47_RS22770 (HUZ47_22735) | 4702506..4703939 | - | 1434 | WP_004894565.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
| HUZ47_RS22775 (HUZ47_22740) | 4703929..4704612 | - | 684 | WP_002887273.1 | copper response regulator transcription factor CusR | - |
| HUZ47_RS22780 (HUZ47_22745) | 4704784..4706169 | + | 1386 | WP_004894567.1 | efflux transporter outer membrane subunit | - |
| HUZ47_RS22785 (HUZ47_22750) | 4706187..4706531 | + | 345 | WP_004894569.1 | cation efflux system protein CusF | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19810.65 Da Isoelectric Point: 5.2614
>T161752 WP_004178461.1 NZ_CP055174:c4702126-4701593 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
Download Length: 534 bp
>T161752 NZ_CP071263:c2629247-2628972 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAATCTCATGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAATCTCATGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9996.46 Da Isoelectric Point: 10.1757
>AT161752 WP_002887278.1 NZ_CP055174:c4702403-4702137 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
Download Length: 267 bp
>AT161752 NZ_CP071263:c2628975-2628616 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060VJ83 |
Antitoxin
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Source | ID | Structure |
|---|---|---|
| PDB | 5ZGN | |
| AlphaFold DB | A0A0H3GLZ1 |