Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2632803..2634391 Replicon chromosome
Accession NZ_CP055174
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag HUZ47_RS12820 Protein ID WP_004892016.1
Coordinates 2632803..2634125 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HUZ47_RS12825 Protein ID WP_004176198.1
Coordinates 2634125..2634391 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ47_RS12805 (HUZ47_12765) 2627859..2630360 + 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -
HUZ47_RS12810 (HUZ47_12770) 2630348..2631352 + 1005 WP_004892012.1 fimbrial protein -
HUZ47_RS12815 (HUZ47_12775) 2631494..2632786 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HUZ47_RS12820 (HUZ47_12780) 2632803..2634125 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ47_RS12825 (HUZ47_12785) 2634125..2634391 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ47_RS12830 (HUZ47_12790) 2634656..2634982 - 327 WP_004892019.1 hydroxyisourate hydrolase -
HUZ47_RS12835 (HUZ47_12795) 2634979..2635479 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HUZ47_RS12840 (HUZ47_12800) 2635457..2636836 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
HUZ47_RS12845 (HUZ47_12805) 2637182..2638336 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
HUZ47_RS12850 (HUZ47_12810) 2638317..2639240 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2427725..2669873 242148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T161749 WP_004892016.1 NZ_CP055174:c2634125-2632803 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T161749 NZ_CP071263:c1950979-1950572 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT161749 WP_004176198.1 NZ_CP055174:c2634391-2634125 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT161749 NZ_CP071263:c1951226-1950960 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References