Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2632803..2634391 Replicon chromosome
Accession NZ_CP055174
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag HUZ47_RS12820 Protein ID WP_004892016.1
Coordinates 2632803..2634125 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HUZ47_RS12825 Protein ID WP_004176198.1
Coordinates 2634125..2634391 (-) Length 89 a.a.

Genomic Context

HUZ47_RS12805HUZ47_RS12810HUZ47_RS12815HUZ47_RS12845HUZ47_RS12820HUZ47_RS12825HUZ47_RS12830HUZ47_RS12835HUZ47_RS12840HUZ47_RS12850
Location: 2627859..2630360 (2502 bp)
Type: Others
Protein ID: WP_004892009.1
Location: 2630348..2631352 (1005 bp)
Type: Others
Protein ID: WP_004892012.1
Location: 2631494..2632786 (1293 bp)
Type: Others
Protein ID: WP_002904794.1
Location: 2637182..2638336 (1155 bp)
Type: Others
Protein ID: WP_004892025.1
Location: 2632803..2634125 (1323 bp)
Type: Toxin
Protein ID: WP_004892016.1
Location: 2634125..2634391 (267 bp)
Type: Antitoxin
Protein ID: WP_004176198.1
Location: 2634656..2634982 (327 bp)
Type: Others
Protein ID: WP_004892019.1
Location: 2634979..2635479 (501 bp)
Type: Others
Protein ID: WP_004892023.1
Location: 2635457..2636836 (1380 bp)
Type: Others
Protein ID: WP_004176204.1
Location: 2638317..2639240 (924 bp)
Type: Others
Protein ID: WP_004892028.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HUZ47_RS12805 (HUZ47_12765)2627859..2630360+2502WP_004892009.1fimbria/pilus outer membrane usher protein-
HUZ47_RS12810 (HUZ47_12770)2630348..2631352+1005WP_004892012.1fimbrial protein-
HUZ47_RS12815 (HUZ47_12775)2631494..2632786+1293WP_002904794.1glycoside hydrolase family 10 protein-
HUZ47_RS12820 (HUZ47_12780)2632803..2634125-1323WP_004892016.1type II toxin-antitoxin system HipA family toxinToxin
HUZ47_RS12825 (HUZ47_12785)2634125..2634391-267WP_004176198.1type II toxin-antitoxin system antitoxin HipBAntitoxin
HUZ47_RS12830 (HUZ47_12790)2634656..2634982-327WP_004892019.1hydroxyisourate hydrolase-
HUZ47_RS12835 (HUZ47_12795)2634979..2635479-501WP_004892023.12-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-
HUZ47_RS12840 (HUZ47_12800)2635457..2636836-1380WP_004176204.1nucleobase:cation symporter-2 family protein-
HUZ47_RS12845 (HUZ47_12805)2637182..2638336+1155WP_004892025.1FAD-dependent urate hydroxylase HpxO-
HUZ47_RS12850 (HUZ47_12810)2638317..2639240-924WP_004892028.1LysR family hpxDE operon transcriptional regulator HpxR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-mgtC / iroE2427725..2669873242148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T161749 WP_004892016.1 NZ_CP055174:c2634125-2632803 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T161749 NZ_CP071263:c1950979-1950572 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT161749 WP_004176198.1 NZ_CP055174:c2634391-2634125 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT161749 NZ_CP071263:c1951226-1950960 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References