Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 782016..782673 Replicon chromosome
Accession NZ_CP055174
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ47_RS03890 Protein ID WP_002916310.1
Coordinates 782263..782673 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ47_RS03885 Protein ID WP_002916312.1
Coordinates 782016..782282 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ47_RS03860 (HUZ47_03850) 777172..778605 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HUZ47_RS03865 (HUZ47_03855) 778724..779452 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ47_RS03870 (HUZ47_03860) 779502..779813 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ47_RS03875 (HUZ47_03865) 779977..780636 + 660 WP_004889817.1 hemolysin III family protein -
HUZ47_RS03880 (HUZ47_03870) 780787..781770 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HUZ47_RS03885 (HUZ47_03875) 782016..782282 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ47_RS03890 (HUZ47_03880) 782263..782673 + 411 WP_002916310.1 protein YgfX Toxin
HUZ47_RS03895 (HUZ47_03885) 782680..783201 - 522 WP_004144730.1 flavodoxin FldB -
HUZ47_RS03900 (HUZ47_03890) 783302..784198 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ47_RS03905 (HUZ47_03895) 784221..784934 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ47_RS03910 (HUZ47_03900) 784940..786673 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161740 WP_002916310.1 NZ_CP055174:782263-782673 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161740 NZ_CP071263:c128580-128386 [Escherichia coli]
ATGCGGTATGAAAAAGTCAAACCATGCCCTTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCGAAGTGTAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161740 WP_002916312.1 NZ_CP055174:782016-782282 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161740 NZ_CP071263:128209-128387 [Escherichia coli]
GAGGACTGAAGTTGCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References