Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4176829..4177664 Replicon chromosome
Accession NZ_CP055167
Organism Shigella flexneri strain STEFF_24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0VTI9
Locus tag HUZ50_RS20090 Protein ID WP_072649755.1
Coordinates 4176829..4177206 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag HUZ50_RS20095 Protein ID WP_001285607.1
Coordinates 4177296..4177664 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ50_RS20065 (4172329) 4172329..4172508 + 180 Protein_3937 peptidase -
HUZ50_RS20070 (4172907) 4172907..4174943 - 2037 WP_239612939.1 hypothetical protein -
HUZ50_RS20075 (4175899) 4175899..4176042 - 144 Protein_3939 hypothetical protein -
HUZ50_RS20080 (4176127) 4176127..4176324 - 198 WP_001327226.1 DUF957 domain-containing protein -
HUZ50_RS20085 (4176344) 4176344..4176832 - 489 WP_000761685.1 DUF5983 family protein -
HUZ50_RS20090 (4176829) 4176829..4177206 - 378 WP_072649755.1 TA system toxin CbtA family protein Toxin
HUZ50_RS20095 (4177296) 4177296..4177664 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ50_RS20100 (4177744) 4177744..4177965 - 222 WP_000692350.1 DUF987 domain-containing protein -
HUZ50_RS20105 (4178052) 4178052..4178528 - 477 WP_001384029.1 RadC family protein -
HUZ50_RS20110 (4178543) 4178543..4179028 - 486 WP_000213722.1 antirestriction protein -
HUZ50_RS20115 (4179120) 4179120..4179938 - 819 WP_001175175.1 DUF932 domain-containing protein -
HUZ50_RS20120 (4180028) 4180028..4180237 - 210 WP_032150870.1 DUF905 family protein -
HUZ50_RS20125 (4180267) 4180267..4180944 - 678 WP_001097301.1 hypothetical protein -
HUZ50_RS20130 (4181092) 4181092..4181772 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR fimC / fimI / fimA / fimE / fimB / papI / papB 4162790..4239750 76960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14216.18 Da        Isoelectric Point: 7.3523

>T161689 WP_072649755.1 NZ_CP055167:c4177206-4176829 [Shigella flexneri]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPWAKQ

Download         Length: 378 bp

>T161689 NZ_CP071248:1673587-1674078 [Bifidobacterium longum subsp. infantis]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATATCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCAGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATAATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT161689 WP_001285607.1 NZ_CP055167:c4177664-4177296 [Shigella flexneri]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT161689 NZ_CP071248:1673225-1673587 [Bifidobacterium longum subsp. infantis]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0VTI9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References