Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3974820..3975439 Replicon chromosome
Accession NZ_CP055162
Organism Klebsiella pneumoniae strain STEFF_9

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUZ51_RS19535 Protein ID WP_002892050.1
Coordinates 3975221..3975439 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUZ51_RS19530 Protein ID WP_002892066.1
Coordinates 3974820..3975194 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ51_RS19520 (3969972) 3969972..3971165 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ51_RS19525 (3971188) 3971188..3974334 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HUZ51_RS19530 (3974820) 3974820..3975194 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUZ51_RS19535 (3975221) 3975221..3975439 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HUZ51_RS19540 (3975598) 3975598..3976164 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUZ51_RS19545 (3976136) 3976136..3976276 - 141 WP_004147370.1 hypothetical protein -
HUZ51_RS19550 (3976297) 3976297..3976767 + 471 WP_002892026.1 YlaC family protein -
HUZ51_RS19555 (3976742) 3976742..3978193 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HUZ51_RS19560 (3978294) 3978294..3978992 + 699 WP_002892021.1 GNAT family protein -
HUZ51_RS19565 (3978989) 3978989..3979129 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUZ51_RS19570 (3979129) 3979129..3979392 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161663 WP_002892050.1 NZ_CP055162:3975221-3975439 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T161663 NZ_CP071242:2040957-2041053 [Serratia marcescens subsp. marcescens ATCC 13880]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT161663 WP_002892066.1 NZ_CP055162:3974820-3975194 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT161663 NZ_CP071242:c2041053-2040913 [Serratia marcescens subsp. marcescens ATCC 13880]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References