Detailed information of TA system TA161661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2686304..2687892
• Replicon: chromosome
• Accession: NZ_CP055162
• Organism: Klebsiella pneumoniae strain STEFF_9

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUZ51_RS13285
• Protein ID: WP_049109073.1
• Coordinates: 2686304..2687626 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HUZ51_RS13290
• Protein ID: WP_002904790.1
• Coordinates: 2687626..2687892 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ51_RS13270 (2681360)	2681360..2683861	+	2502	WP_004190161.1	fimbria/pilus outer membrane usher protein	-
HUZ51_RS13275 (2683849)	2683849..2684853	+	1005	WP_004190163.1	fimbrial protein	-
HUZ51_RS13280 (2684995)	2684995..2686287	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HUZ51_RS13285 (2686304)	2686304..2687626	-	1323	WP_049109073.1	type II toxin-antitoxin system HipA family toxin	Toxin
HUZ51_RS13290 (2687626)	2687626..2687892	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HUZ51_RS13295 (2688279)	2688279..2688605	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
HUZ51_RS13300 (2688602)	2688602..2689102	-	501	WP_186944391.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HUZ51_RS13305 (2689080)	2689080..2690459	-	1380	WP_004199850.1	nucleobase:cation symporter-2 family protein	-
HUZ51_RS13310 (2690805)	2690805..2691959	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HUZ51_RS13315 (2691940)	2691940..2692863	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49115.40 Da
• Isoelectric Point: 7.5357

>T161661 WP_049109073.1 NZ_CP055162:c2687626-2686304 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPAGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T161661 NZ_CP071242:c1109292-1109089 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT161661 WP_002904790.1 NZ_CP055162:c2687892-2687626 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT161661 NZ_CP071242:c1109710-1109342 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8