Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837179..837836 Replicon chromosome
Accession NZ_CP055162
Organism Klebsiella pneumoniae strain STEFF_9

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ51_RS04135 Protein ID WP_002916310.1
Coordinates 837426..837836 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ51_RS04130 Protein ID WP_002916312.1
Coordinates 837179..837445 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ51_RS04105 (832335) 832335..833768 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
HUZ51_RS04110 (833887) 833887..834615 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ51_RS04115 (834665) 834665..834976 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ51_RS04120 (835140) 835140..835799 + 660 WP_002916317.1 hemolysin III family protein -
HUZ51_RS04125 (835950) 835950..836933 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
HUZ51_RS04130 (837179) 837179..837445 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ51_RS04135 (837426) 837426..837836 + 411 WP_002916310.1 protein YgfX Toxin
HUZ51_RS04140 (837843) 837843..838364 - 522 WP_004144730.1 flavodoxin FldB -
HUZ51_RS04145 (838465) 838465..839361 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ51_RS04150 (839384) 839384..840097 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ51_RS04155 (840103) 840103..841836 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161652 WP_002916310.1 NZ_CP055162:837426-837836 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161652 NZ_CP071240:c1108033-1107830 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161652 WP_002916312.1 NZ_CP055162:837179-837445 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161652 NZ_CP071240:c1108451-1108083 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References