Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 690518..691197 Replicon chromosome
Accession NZ_CP055162
Organism Klebsiella pneumoniae strain STEFF_9

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag HUZ51_RS03390 Protein ID WP_020324801.1
Coordinates 690856..691197 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag HUZ51_RS03385 Protein ID WP_020324792.1
Coordinates 690518..690835 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ51_RS03360 (685732) 685732..688884 + 3153 WP_022631414.1 AIDA repeat-containing protein -
HUZ51_RS03365 (688977) 688977..689216 + 240 WP_020324820.1 DUF905 domain-containing protein -
HUZ51_RS03370 (689319) 689319..689777 + 459 WP_020324813.1 antirestriction protein -
HUZ51_RS03375 (689793) 689793..690269 + 477 WP_020324797.1 RadC family protein -
HUZ51_RS03380 (690278) 690278..690505 + 228 WP_020324796.1 DUF987 domain-containing protein -
HUZ51_RS03385 (690518) 690518..690835 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ51_RS03390 (690856) 690856..691197 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
HUZ51_RS03395 (691313) 691313..692146 + 834 WP_020324805.1 DUF4942 domain-containing protein -
HUZ51_RS03405 (692449) 692449..692955 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
HUZ51_RS03410 (693055) 693055..694896 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 643731..692146 48415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T161651 WP_020324801.1 NZ_CP055162:690856-691197 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T161651 NZ_CP071240:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT161651 WP_020324792.1 NZ_CP055162:690518-690835 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT161651 NZ_CP071240:55069-55329 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References