Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4038731..4039352 Replicon chromosome
Accession NZ_CP055161
Organism Serratia marcescens strain JW-CZ2

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HUW55_RS19190 Protein ID WP_004940313.1
Coordinates 4039149..4039352 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HUW55_RS19185 Protein ID WP_004940312.1
Coordinates 4038731..4039099 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW55_RS19155 4034828..4035082 + 255 WP_004940303.1 type B 50S ribosomal protein L31 -
HUW55_RS19160 4035095..4035235 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
HUW55_RS19165 4035343..4036221 - 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
HUW55_RS19170 4036247..4037104 - 858 WP_164052909.1 metal ABC transporter permease -
HUW55_RS19175 4037101..4037814 - 714 WP_079451039.1 ABC transporter ATP-binding protein -
HUW55_RS19180 4038219..4038572 + 354 WP_016928845.1 hypothetical protein -
HUW55_RS19185 4038731..4039099 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
HUW55_RS19190 4039149..4039352 + 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
HUW55_RS19200 4039936..4040250 + 315 WP_176063601.1 MGMT family protein -
HUW55_RS19205 4040315..4040806 - 492 WP_016928846.1 YbaY family lipoprotein -
HUW55_RS19210 4041037..4041900 + 864 WP_016928847.1 acyl-CoA thioesterase II -
HUW55_RS19215 4041991..4043277 - 1287 WP_049299675.1 ammonium transporter AmtB -
HUW55_RS19220 4043313..4043651 - 339 WP_049299676.1 P-II family nitrogen regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T161649 WP_004940313.1 NZ_CP055161:4039149-4039352 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T161649 NZ_CP071238:c4454564-4454310 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT161649 WP_004940312.1 NZ_CP055161:4038731-4039099 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT161649 NZ_CP071238:c4454310-4453969 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9


Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References