Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4038731..4039352 | Replicon | chromosome |
Accession | NZ_CP055161 | ||
Organism | Serratia marcescens strain JW-CZ2 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A8B4G7F9 |
Locus tag | HUW55_RS19190 | Protein ID | WP_004940313.1 |
Coordinates | 4039149..4039352 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A2X2G5J9 |
Locus tag | HUW55_RS19185 | Protein ID | WP_004940312.1 |
Coordinates | 4038731..4039099 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUW55_RS19155 | 4034828..4035082 | + | 255 | WP_004940303.1 | type B 50S ribosomal protein L31 | - |
HUW55_RS19160 | 4035095..4035235 | + | 141 | WP_004940304.1 | type B 50S ribosomal protein L36 | - |
HUW55_RS19165 | 4035343..4036221 | - | 879 | WP_016928843.1 | metal ABC transporter substrate-binding protein | - |
HUW55_RS19170 | 4036247..4037104 | - | 858 | WP_164052909.1 | metal ABC transporter permease | - |
HUW55_RS19175 | 4037101..4037814 | - | 714 | WP_079451039.1 | ABC transporter ATP-binding protein | - |
HUW55_RS19180 | 4038219..4038572 | + | 354 | WP_016928845.1 | hypothetical protein | - |
HUW55_RS19185 | 4038731..4039099 | + | 369 | WP_004940312.1 | Hha toxicity modulator TomB | Antitoxin |
HUW55_RS19190 | 4039149..4039352 | + | 204 | WP_004940313.1 | hemolysin expression modulator Hha | Toxin |
HUW55_RS19200 | 4039936..4040250 | + | 315 | WP_176063601.1 | MGMT family protein | - |
HUW55_RS19205 | 4040315..4040806 | - | 492 | WP_016928846.1 | YbaY family lipoprotein | - |
HUW55_RS19210 | 4041037..4041900 | + | 864 | WP_016928847.1 | acyl-CoA thioesterase II | - |
HUW55_RS19215 | 4041991..4043277 | - | 1287 | WP_049299675.1 | ammonium transporter AmtB | - |
HUW55_RS19220 | 4043313..4043651 | - | 339 | WP_049299676.1 | P-II family nitrogen regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8107.37 Da Isoelectric Point: 6.9756
>T161649 WP_004940313.1 NZ_CP055161:4039149-4039352 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
Download Length: 204 bp
>T161649 NZ_CP071238:c4454564-4454310 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14261.95 Da Isoelectric Point: 4.4314
>AT161649 WP_004940312.1 NZ_CP055161:4038731-4039099 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT
Download Length: 369 bp
>AT161649 NZ_CP071238:c4454310-4453969 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B4G7F9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2X2G5J9 |