Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1403933..1404589 Replicon chromosome
Accession NZ_CP055161
Organism Serratia marcescens strain JW-CZ2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUW55_RS06495 Protein ID WP_143779310.1
Coordinates 1404200..1404589 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag HUW55_RS06490 Protein ID WP_004941563.1
Coordinates 1403933..1404196 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW55_RS06465 1398971..1400185 - 1215 WP_016926700.1 D-galactonate dehydratase family protein -
HUW55_RS06470 1400354..1401259 - 906 WP_143779312.1 lipid kinase YegS -
HUW55_RS06475 1401509..1401670 + 162 WP_162838157.1 hypothetical protein -
HUW55_RS06480 1401727..1403079 - 1353 WP_049299962.1 tRNA 5-hydroxyuridine modification protein YegQ -
HUW55_RS06485 1403258..1403596 - 339 WP_004941561.1 YegP family protein -
HUW55_RS06490 1403933..1404196 + 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HUW55_RS06495 1404200..1404589 + 390 WP_143779310.1 type II toxin-antitoxin system VapC family toxin Toxin
HUW55_RS06500 1404597..1405313 - 717 WP_004941568.1 two-component system response regulator BaeR -
HUW55_RS06505 1405313..1406695 - 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
HUW55_RS06510 1406692..1408122 - 1431 WP_016926706.1 multidrug transporter subunit MdtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14385.64 Da        Isoelectric Point: 8.4983

>T161637 WP_143779310.1 NZ_CP055161:1404200-1404589 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T161637 NZ_CP071236:c3110826-3110428 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT161637 WP_004941563.1 NZ_CP055161:1403933-1404196 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT161637 NZ_CP071236:c3111059-3110826 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References