Detailed information of TA system TA161630

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3541050..3541692
• Replicon: chromosome
• Accession: NZ_CP055159
• Organism: Shewanella algae strain 2NE11

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A0A5N5U1D5
• Locus tag: HU689_RS15780
• Protein ID: WP_025010549.1
• Coordinates: 3541050..3541472 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: HU689_RS15785
• Protein ID: WP_028779782.1
• Coordinates: 3541453..3541692 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU689_RS15755	3536567..3537046	-	480	WP_096140813.1	SoxR reducing system RseC family protein	-
HU689_RS15760	3537057..3537989	-	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
HU689_RS15765	3537999..3538619	-	621	WP_025887842.1	anti-sigma factor	-
HU689_RS15770	3538644..3539222	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
HU689_RS15775	3539422..3541032	+	1611	WP_144134861.1	L-aspartate oxidase	-
HU689_RS15780	3541050..3541472	-	423	WP_025010549.1	hypothetical protein	Toxin
HU689_RS15785	3541453..3541692	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
HU689_RS15790	3541791..3542699	-	909	WP_025010548.1	transcriptional activator NhaR	-
HU689_RS15795	3542716..3543084	-	369	WP_096141176.1	hypothetical protein	-
HU689_RS15800	3543096..3544271	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
HU689_RS15805	3544388..3545182	-	795	WP_129978430.1	thymidylate synthase	-
HU689_RS15810	3545182..3546009	-	828	WP_071238279.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16309.86 Da
• Isoelectric Point: 7.0359

>T161630 WP_025010549.1 NZ_CP055159:c3541472-3541050 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T161630 NZ_CP071234:c4165719-4165297 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT161630 WP_028779782.1 NZ_CP055159:c3541692-3541453 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT161630 NZ_CP071234:c4165966-4165700 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1