Detailed information of TA system TA161629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1142406..1143551
• Replicon: chromosome
• Accession: NZ_CP055159
• Organism: Shewanella algae strain 2NE11

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HU689_RS05090
• Protein ID: WP_045283715.1
• Coordinates: 1142805..1143551 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7X5Z3H2
• Locus tag: HU689_RS05085
• Protein ID: WP_025011540.1
• Coordinates: 1142406..1142768 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU689_RS05070	1139870..1140607	-	738	WP_044733833.1	DsbA family protein	-
HU689_RS05075	1140748..1141389	-	642	WP_025011542.1	DnaJ domain-containing protein	-
HU689_RS05080	1141520..1142173	-	654	WP_045283714.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
HU689_RS05085	1142406..1142768	+	363	WP_025011540.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
HU689_RS05090	1142805..1143551	+	747	WP_045283715.1	RES family NAD+ phosphorylase	Toxin
HU689_RS05095	1143565..1145130	-	1566	WP_107006061.1	hypothetical protein	-
HU689_RS05100	1145229..1145954	-	726	WP_107353204.1	amino acid ABC transporter ATP-binding protein	-
HU689_RS05105	1145947..1146624	-	678	WP_025011537.1	amino acid ABC transporter permease	-
HU689_RS05110	1146631..1147356	-	726	WP_045283734.1	basic amino acid ABC transporter substrate-binding protein	-
HU689_RS05115	1147768..1148334	+	567	WP_025011535.1	hypoxanthine phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-118)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28826.60 Da
• Isoelectric Point: 4.6800

>T161629 WP_045283715.1 NZ_CP055159:1142805-1143551 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQEVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSAAKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Nucleotide

• Length: 747 bp

>T161629 NZ_CP071234:c3787991-3787602 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13125.14 Da
• Isoelectric Point: 10.4675

>AT161629 WP_025011540.1 NZ_CP055159:1142406-1142768 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT161629 NZ_CP071234:c3788258-3787995 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z3H2