Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4525905..4526530 Replicon chromosome
Accession NZ_CP055113
Organism Shigella flexneri strain SWHIN_101

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUZ81_RS21900 Protein ID WP_000911330.1
Coordinates 4526132..4526530 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HUZ81_RS21895 Protein ID WP_000450524.1
Coordinates 4525905..4526132 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ81_RS21870 (4521708) 4521708..4522178 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
HUZ81_RS21875 (4522178) 4522178..4522750 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HUZ81_RS21880 (4522896) 4522896..4523774 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
HUZ81_RS21885 (4523791) 4523791..4524825 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
HUZ81_RS21890 (4525038) 4525038..4525751 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HUZ81_RS21895 (4525905) 4525905..4526132 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HUZ81_RS21900 (4526132) 4526132..4526530 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ81_RS21905 (4526677) 4526677..4527540 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HUZ81_RS21910 (4527555) 4527555..4529570 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
HUZ81_RS21915 (4529644) 4529644..4530342 + 699 WP_000679812.1 esterase -
HUZ81_RS21920 (4530423) 4530423..4530623 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T161602 WP_000911330.1 NZ_CP055113:4526132-4526530 [Shigella flexneri]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T161602 NZ_CP071228:c3786694-3786305 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT161602 WP_000450524.1 NZ_CP055113:4525905-4526132 [Shigella flexneri]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT161602 NZ_CP071228:c3786961-3786698 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References