Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 220242..220819 Replicon plasmid unnamed1
Accession NZ_CP055107
Organism Klebsiella pneumoniae strain SWHIN_106

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HUZ83_RS26520 Protein ID WP_239612467.1
Coordinates 220487..220819 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HUZ83_RS26515 Protein ID WP_239612466.1
Coordinates 220242..220487 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ83_RS26485 (HUZ83_26410) 215502..216572 - 1071 WP_239612461.1 hypothetical protein -
HUZ83_RS26490 (HUZ83_26415) 216846..217191 + 346 Protein_227 transposase -
HUZ83_RS26495 (HUZ83_26420) 217388..217720 - 333 WP_239612462.1 IS200/IS605 family transposase -
HUZ83_RS26500 (HUZ83_26425) 218081..218569 - 489 WP_239612463.1 type II toxin-antitoxin system YhaV family toxin -
HUZ83_RS26505 (HUZ83_26430) 218593..218934 - 342 WP_239612464.1 type II toxin-antitoxin system PrlF family antitoxin -
HUZ83_RS26510 (HUZ83_26435) 219692..220027 + 336 WP_239612465.1 hypothetical protein -
HUZ83_RS26515 (HUZ83_26440) 220242..220487 + 246 WP_239612466.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HUZ83_RS26520 (HUZ83_26445) 220487..220819 + 333 WP_239612467.1 endoribonuclease MazF Toxin
HUZ83_RS26525 (HUZ83_26450) 221481..221948 + 468 WP_124737156.1 hypothetical protein -
HUZ83_RS26530 (HUZ83_26455) 221993..222199 - 207 WP_063938351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..301800 301800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11985.82 Da        Isoelectric Point: 7.7467

>T161543 WP_239612467.1 NZ_CP055107:220487-220819 [Klebsiella pneumoniae]
MVKRYVPDAGDLIWIDFDPVAGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTSQIKGYPFEVTLSGSKEGVALSDQVTCV
DWRDRKVLKKDSVNSSELAEIRAKAKALIG

Download         Length: 333 bp

>T161543 NZ_CP071216:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8699.99 Da        Isoelectric Point: 4.9849

>AT161543 WP_239612466.1 NZ_CP055107:220242-220487 [Klebsiella pneumoniae]
MAQAIVKKWGNSPSVRLPVAVMKAASLNVDDTVDIEVEDGRIIIVPVRQKEYSLDALLAGISTDNLHGKADFGPAQGKEQ
L

Download         Length: 246 bp

>AT161543 NZ_CP071216:55069-55329 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References