Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 142817..143727 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055107 | ||
| Organism | Klebsiella pneumoniae strain SWHIN_106 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | HUZ83_RS26090 | Protein ID | WP_004026354.1 |
| Coordinates | 142817..143287 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | HUZ83_RS26095 | Protein ID | WP_004181895.1 |
| Coordinates | 143284..143727 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ83_RS26045 (HUZ83_25980) | 137866..138183 | - | 318 | WP_080895857.1 | hypothetical protein | - |
| HUZ83_RS26050 (HUZ83_25985) | 138199..138549 | - | 351 | WP_239612497.1 | hypothetical protein | - |
| HUZ83_RS26055 (HUZ83_25990) | 138546..138818 | - | 273 | WP_110244253.1 | hypothetical protein | - |
| HUZ83_RS26060 (HUZ83_25995) | 139008..139493 | + | 486 | WP_239612498.1 | cytoplasmic protein | - |
| HUZ83_RS26065 | 139737..139835 | - | 99 | WP_229551541.1 | Hok/Gef family protein | - |
| HUZ83_RS26070 | 139810..139866 | - | 57 | Protein_143 | hypothetical protein | - |
| HUZ83_RS26075 (HUZ83_26005) | 139967..141010 | + | 1044 | WP_117050918.1 | IS481-like element ISKpn28 family transposase | - |
| HUZ83_RS26080 (HUZ83_26010) | 141006..141748 | - | 743 | Protein_145 | IS3-like element ISKpn8 family transposase | - |
| HUZ83_RS26085 (HUZ83_26015) | 142447..142707 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| HUZ83_RS26090 (HUZ83_26020) | 142817..143287 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| HUZ83_RS26095 (HUZ83_26025) | 143284..143727 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| HUZ83_RS26100 (HUZ83_26030) | 143828..144505 | - | 678 | Protein_149 | DUF4113 domain-containing protein | - |
| HUZ83_RS26105 (HUZ83_26035) | 144565..145533 | - | 969 | WP_162893603.1 | IS5-like element IS903B family transposase | - |
| HUZ83_RS26110 (HUZ83_26040) | 145513..145866 | + | 354 | WP_117339737.1 | hypothetical protein | - |
| HUZ83_RS26115 (HUZ83_26045) | 145977..146513 | + | 537 | WP_123677973.1 | hypothetical protein | - |
| HUZ83_RS26120 (HUZ83_26050) | 146522..146980 | + | 459 | WP_032414405.1 | type II toxin-antitoxin system YafO family toxin | - |
| HUZ83_RS26125 (HUZ83_26055) | 147097..148122 | + | 1026 | WP_001101446.1 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..301800 | 301800 | |
| - | inside | IScluster/Tn | - | - | 139967..151774 | 11807 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T161540 WP_004026354.1 NZ_CP055107:c143287-142817 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T161540 NZ_CP071214:c4164419-4163997 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT161540 WP_004181895.1 NZ_CP055107:c143727-143284 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT161540 NZ_CP071214:c4164666-4164400 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |