Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4551229..4552064 Replicon chromosome
Accession NZ_CP055106
Organism Klebsiella pneumoniae strain SWHIN_106

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag HUZ83_RS22305 Protein ID WP_001559913.1
Coordinates 4551229..4551606 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag HUZ83_RS22310 Protein ID WP_032408847.1
Coordinates 4551696..4552064 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ83_RS22265 (4546493) 4546493..4546759 + 267 WP_004178415.1 hypothetical protein -
HUZ83_RS22270 (4546759) 4546759..4547431 + 673 Protein_4369 DUF4400 domain-containing protein -
HUZ83_RS22275 (4547442) 4547442..4548326 + 885 WP_004192285.1 RES domain-containing protein -
HUZ83_RS22280 (4548525) 4548525..4548713 - 189 Protein_4371 transposase -
HUZ83_RS22285 (4548730) 4548730..4549841 - 1112 Protein_4372 IS3 family transposase -
HUZ83_RS22290 (4550293) 4550293..4550442 - 150 Protein_4373 restriction endonuclease subunit M -
HUZ83_RS22295 (4550527) 4550527..4550724 - 198 WP_032408848.1 DUF957 domain-containing protein -
HUZ83_RS22300 (4550744) 4550744..4551232 - 489 WP_001559914.1 DUF5983 family protein -
HUZ83_RS22305 (4551229) 4551229..4551606 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
HUZ83_RS22310 (4551696) 4551696..4552064 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ83_RS22315 (4552241) 4552241..4552462 - 222 WP_000692300.1 DUF987 domain-containing protein -
HUZ83_RS22320 (4552531) 4552531..4553007 - 477 WP_032408846.1 RadC family protein -
HUZ83_RS22325 (4553022) 4553022..4553507 - 486 WP_088607457.1 antirestriction protein -
HUZ83_RS22330 (4553599) 4553599..4554417 - 819 WP_001559911.1 DUF932 domain-containing protein -
HUZ83_RS22335 (4554517) 4554517..4554750 - 234 WP_001119729.1 DUF905 family protein -
HUZ83_RS22340 (4554829) 4554829..4555284 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T161535 WP_001559913.1 NZ_CP055106:c4551606-4551229 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T161535 NZ_CP071214:c1108033-1107830 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT161535 WP_032408847.1 NZ_CP055106:c4552064-4551696 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT161535 NZ_CP071214:c1108451-1108083 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References