Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3890811..3891430 Replicon chromosome
Accession NZ_CP055106
Organism Klebsiella pneumoniae strain SWHIN_106

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUZ83_RS19100 Protein ID WP_002892050.1
Coordinates 3891212..3891430 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUZ83_RS19095 Protein ID WP_002892066.1
Coordinates 3890811..3891185 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ83_RS19085 (3885963) 3885963..3887156 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ83_RS19090 (3887179) 3887179..3890325 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HUZ83_RS19095 (3890811) 3890811..3891185 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUZ83_RS19100 (3891212) 3891212..3891430 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HUZ83_RS19105 (3891589) 3891589..3892155 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUZ83_RS19110 (3892127) 3892127..3892267 - 141 WP_004147370.1 hypothetical protein -
HUZ83_RS19115 (3892288) 3892288..3892758 + 471 WP_002892026.1 YlaC family protein -
HUZ83_RS19120 (3892733) 3892733..3894184 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HUZ83_RS19125 (3894285) 3894285..3894983 + 699 WP_004177238.1 GNAT family protein -
HUZ83_RS19130 (3894980) 3894980..3895120 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUZ83_RS19135 (3895120) 3895120..3895383 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161533 WP_002892050.1 NZ_CP055106:3891212-3891430 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T161533 NZ_CP071212:4534543-4534854 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCATTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT161533 WP_002892066.1 NZ_CP055106:3890811-3891185 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT161533 NZ_CP071212:4534851-4535273 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTACCGGGAAGCGCTTGAATTGGTGGAATACCTGCTGGAAAACGACGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAGTTACCACAGGGGGTAGCC
GCGCTTCGCGTCCTTATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGTAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References