Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 8822..9414 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP055102 | ||
| Organism | Shigella flexneri strain SWHIN_107 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1I9ZJC5 |
| Locus tag | HUZ84_RS24875 | Protein ID | WP_000513532.1 |
| Coordinates | 8822..9070 (+) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A1I9ZJ49 |
| Locus tag | HUZ84_RS24880 | Protein ID | WP_000681609.1 |
| Coordinates | 9067..9414 (+) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ84_RS24835 (HUZ84_24620) | 3911..4576 | - | 666 | WP_000532149.1 | division plane positioning ATPase MipZ | - |
| HUZ84_RS24840 (HUZ84_24625) | 5174..5503 | + | 330 | WP_000855121.1 | hypothetical protein | - |
| HUZ84_RS24845 (HUZ84_24630) | 6082..6405 | + | 324 | WP_000427402.1 | hypothetical protein | - |
| HUZ84_RS24850 (HUZ84_24635) | 6446..6655 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| HUZ84_RS24855 (HUZ84_24640) | 6752..6976 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| HUZ84_RS24860 (HUZ84_24645) | 7028..7288 | + | 261 | WP_000702247.1 | hypothetical protein | - |
| HUZ84_RS24865 (HUZ84_24650) | 7278..7529 | + | 252 | WP_001132407.1 | transcriptional regulator | - |
| HUZ84_RS24870 (HUZ84_24655) | 8079..8357 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| HUZ84_RS24875 (HUZ84_24660) | 8822..9070 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| HUZ84_RS24880 (HUZ84_24665) | 9067..9414 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| HUZ84_RS24885 | 9502..9945 | - | 444 | WP_023223351.1 | hypothetical protein | - |
| HUZ84_RS24890 (HUZ84_24675) | 10186..10485 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HUZ84_RS24895 (HUZ84_24680) | 10745..11071 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| HUZ84_RS24900 (HUZ84_24685) | 11073..11411 | - | 339 | WP_029797038.1 | hypothetical protein | - |
| HUZ84_RS24905 | 11391..11513 | - | 123 | Protein_20 | hypothetical protein | - |
| HUZ84_RS24910 (HUZ84_24690) | 11533..12240 | - | 708 | WP_000108794.1 | hypothetical protein | - |
| HUZ84_RS24915 (HUZ84_24695) | 12242..12994 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
| HUZ84_RS24920 (HUZ84_24700) | 13012..13413 | - | 402 | WP_021575837.1 | hypothetical protein | - |
| HUZ84_RS24925 (HUZ84_24705) | 13782..14123 | + | 342 | WP_000730722.1 | plasmid mobilization relaxosome protein MobC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..58696 | 58696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9378.03 Da Isoelectric Point: 10.4800
>T161521 WP_000513532.1 NZ_CP055102:8822-9070 [Shigella flexneri]
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
Download Length: 249 bp
>T161521 NZ_CP071210:c3786712-3786323 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13206.97 Da Isoelectric Point: 4.8313
>AT161521 WP_000681609.1 NZ_CP055102:9067-9414 [Shigella flexneri]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA
Download Length: 348 bp
>AT161521 NZ_CP071210:c3786979-3786716 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1I9ZJC5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1I9ZJ49 |